PYGO2 and NF2

Number of citations of the paper that reports this interaction (PMID 20937768)
10

Data Source:
BioGRID (pull down)

		PYGO2	NF2
Gene Name		pygopus family PHD finger 2	neurofibromin 2 (merlin)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleolus Cytoplasm Early Endosome Cytoskeleton Plasma Membrane Adherens Junction Membrane Extrinsic Component Of Membrane Lamellipodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Histone Acetyltransferase Regulator Activity Histone Binding	Actin Binding Protein Binding
	Biological Process	In Utero Embryonic Development Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Post-embryonic Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Palate Development Canonical Wnt Signaling Pathway	Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Ectoderm Development Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Schwann Cell Proliferation Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Protein Stability Regulation Of Hippo Signaling Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Stress Fiber Assembly Lens Fiber Cell Differentiation Regulation Of Protein Localization To Nucleus Regulation Of Neural Precursor Cell Proliferation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		5 interactors: BCL9 KAT2A NF2 SUPT3H TRRAP	24 interactors: AGAP2 AKT1 CCNB1IP1 CD44 CTNNB1 ERBB2 EZR HGS ITGB1 KDM1A MED28 PAK1 PXN PYGO2 RALGDS SCHIP1 SDCBP SGSM3 SLC9A3R1 SPTBN1 TARBP2 TSC1 VPRBP XPO1
Entrez ID		90780	4771
HPRD ID		06065	06980
Ensembl ID		ENSG00000163348	ENSG00000186575
Uniprot IDs		Q5T170 Q9BRQ0	P35240
PDB IDs		2XB1	1H4R 3U8Z
Enriched GO Terms of Interacting Partners?		Histone Deubiquitination Protein Deubiquitination Histone Acetylation Internal Peptidyl-lysine Acetylation Protein Modification By Small Protein Removal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Peptidyl-lysine Modification Histone H3 Acetylation Histone Modification Histone H4 Acetylation Chromatin Modification Chromatin Organization Regulation Of Protein Stability Regulation Of Gene Expression Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromosome Organization Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Histone H3-K14 Acetylation Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Schwann Cell Proliferation Telencephalon Development Organelle Organization Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Hippo Signaling Histone H4-K12 Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Histone H2A Acetylation Glial Cell Proliferation Regulation Of Metabolic Process Forebrain Development Tissue Development Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Gluconeogenesis Growth Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of JAK-STAT Cascade Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Ectoderm Development	Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cell Development Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Cell Projection Organization Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Growth Factor Axon Guidance Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Anatomical Structure Development Positive Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Localization Regulation Of Protein Kinase Activity Cell Morphogenesis Cell-matrix Adhesion Signal Transduction Nervous System Development Axonogenesis Cellular Response To Organic Substance Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Protein Localization Regulation Of Catalytic Activity Multicellular Organismal Development Developmental Process Cellular Localization Anatomical Structure Morphogenesis Axon Development Response To Stimulus Cellular Response To Growth Factor Stimulus
Tagcloud ?		catenin compartment converge depilation dispensable emerged epithelia excessive facilitates follicle hair holds homeobox homolog hyperactivation hyperplasia keratinocytes lhx2 lim maximizes prime progenitor prominent promise pygopus regeneration stem trichofolliculoma wnt	22q allele alleles analysed assumed candidates carcinomas colorectal coupled cys digestive e1a gastric gene heterozygosity inactivation located missense mutation neurofibromatosis p300 participates rich sequencing somatic sscp suppressor though thought
Tagcloud (Difference) ?		catenin compartment converge depilation dispensable emerged epithelia excessive facilitates follicle hair holds homeobox homolog hyperactivation hyperplasia keratinocytes lhx2 lim maximizes prime progenitor prominent promise pygopus regeneration stem trichofolliculoma wnt	22q allele alleles analysed assumed candidates carcinomas colorectal coupled cys digestive e1a gastric gene heterozygosity inactivation located missense mutation neurofibromatosis p300 participates rich sequencing somatic sscp suppressor though thought
Tagcloud (Intersection) ?