PYGO2 and BCL9

Number of citations of the paper that reports this interaction (PubMedID 14612447)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PYGO2	BCL9
Description		pygopus family PHD finger 2	BCL9 transcription coactivator
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Beta-catenin-TCF Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cis-Golgi Network Sarcoplasm Beta-catenin-TCF Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Histone Acetyltransferase Regulator Activity Histone Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Beta-catenin Binding
	Biological Process	Kidney Development Lens Development In Camera-type Eye Spermatid Development Spermatid Nucleus Differentiation Brain Development Wnt Signaling Pathway Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Developmental Growth Roof Of Mouth Development Canonical Wnt Signaling Pathway	Transcription By RNA Polymerase II Myotube Differentiation Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Skeletal Muscle Cell Differentiation Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)	Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Schizophrenia (negative symptoms) ( 23382809) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 25760438)
Interacting Genes		7 interacting genes: AKT1 BCL9 DCAF1 KAT2A NF2 SUPT3H TRRAP	6 interacting genes: BCL2L13 CTNNB1 MAP1LC3A PYGO1 PYGO2 USP9X
Entrez ID		90780	607
HPRD ID		06065	04000
Ensembl ID		ENSG00000163348	ENSG00000116128
Uniprot IDs		Q5T170 Q9BRQ0	O00512 Q1JQ81
PDB IDs		2XB1 4UP0 4UP5 8HIB	2GL7 2VP7 2VPB 2VPD 2VPE 2VPG 3SL9 8Y0P
Enriched GO Terms of Interacting Partners?		Transcription Factor TFTC Complex SAGA Complex Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Nerve Growth Factor Regulation Of Organelle Assembly Positive Regulation Of DNA-templated Transcription Cellular Response To Nerve Growth Factor Stimulus Transcription Coactivator Activity Regulation Of DNA Repair Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Striated Muscle Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of TRNA Methylation Regulation Of Cell Cycle Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Tumor Necrosis Factor Nucleoplasm Muscle Cell Differentiation Negative Regulation Of Protein Localization To Lysosome Histone H3K9 Acetyltransferase Activity Carbohydrate Biosynthetic Process Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Response To Tumor Necrosis Factor Cellular Response To Rapamycin Glucose Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Nucleus	Canonical Wnt Signaling Pathway Spermatid Nucleus Differentiation Beta-catenin-TCF Complex Kidney Development Germ Cell Development Wnt Signaling Pathway Mitophagy Developmental Growth Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Reproductive Process Neuron Projection Extension Glial Cell Fate Determination Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Developmental Cell Growth Organelle Organization K11-linked Deubiquitinase Activity Autophagy Of Mitochondrion Nucleus Organization Spermatid Development Histone Acetyltransferase Regulator Activity Oviduct Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Fungiform Papilla Formation Beta-catenin-TCF7L2 Complex Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Centriole-centriole Cohesion Embryonic Skeletal Limb Joint Morphogenesis Lung Induction Neuron Migration Catenin-TCF7L2 Complex Developmental Growth Involved In Morphogenesis Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Glial Cell-neuron Signaling
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