GATA2 and NFIB

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		GATA2	NFIB
Description		GATA binding protein 2	nuclear factor I B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm	Chromatin Fibrillar Center Nucleus Nucleoplasm Cerebellar Mossy Fiber
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Urogenital System Development Cell Fate Determination Neuron Migration Embryonic Placenta Development Glandular Epithelial Cell Differentiation Glandular Epithelial Cell Maturation Hematopoietic Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Phagocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Primitive Erythrocyte Differentiation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Differentiation Central Nervous System Neuron Development Pituitary Gland Development Myeloid Cell Differentiation Cell Differentiation Neuron Differentiation Response To Lipid Somatic Stem Cell Population Maintenance Eosinophil Fate Commitment Inner Ear Morphogenesis Neuron Maturation Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment System Development Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Regulation Of Developmental Process Brown Fat Cell Differentiation Positive Regulation Of Phagocytosis, Engulfment Thyroid-stimulating Hormone-secreting Cell Differentiation Definitive Hemopoiesis Semicircular Canal Development Vascular Wound Healing Neuroendocrine Cell Differentiation Neural Precursor Cell Proliferation Hematopoietic Stem Cell Homeostasis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cochlea Development GABAergic Neuron Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of MiRNA Transcription Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Forebrain Neuron Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Tissue Homeostasis Chondrocyte Differentiation Glandular Epithelial Cell Differentiation DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Cell Population Proliferation Response To Wounding Response To Bacterium Glial Cell Differentiation Exit From Mitosis Gene Expression Glial Cell Proliferation Stem Cell Population Maintenance Principal Sensory Nucleus Of Trigeminal Nerve Development Glial Cell Fate Specification Cell Proliferation In Forebrain Anterior Commissure Morphogenesis Neurogenesis Lung Development Forebrain Development Hindbrain Development Regeneration Negative Regulation Of DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Generation Of Neurons Retina Development In Camera-type Eye Club Cell Differentiation Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Salivary Gland Cavitation Cell Differentiation Involved In Salivary Gland Development Lung Ciliated Cell Differentiation Neural Precursor Cell Proliferation Commissural Neuron Axon Guidance Stem Cell Proliferation Negative Regulation Of MiRNA Transcription Negative Regulation Of Stem Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Basophil count ( 28031487) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) Eosinophil count ( 19198610) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Preterm birth (maternal effect) ( 28877031) Prostate cancer ( 31562322) Pulse pressure ( 30578418 28135244 27841878) Systolic blood pressure ( 27841878) White blood cell count ( 21738480) White blood cell count (basophil) ( 28158719) White blood cell count (eosinophil) ( 28158719) White blood cell types ( 21738478)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcoholic chronic pancreatitis ( 28754779) Alzheimer's disease biomarkers ( 23419831) Ankle injury ( 28957384) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metastasis at diagnosis in osteosarcoma ( 26084801) Red blood cell count ( 32888494)
Interacting Genes		49 interacting genes: ADAMTSL4 AKT1 CDK1 CEBPA COP1 CYSRT1 FBXW7 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 KRTAP11-1 KRTAP13-3 KRTAP21-2 KRTAP3-1 KRTAP6-3 KRTAP7-1 KRTAP8-1 LMO2 MAPK1 MDFI MSX2 NFIA NFIB NFIC NOTCH2NLA PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RBPMS RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1	17 interacting genes: ELK3 ERG ETV7 FOS FOXL1 GATA2 GATA3 KLF16 KLF8 LHX2 LHX3 NFIC NFIX NHLH1 RFX1 SFN TBXT
Entrez ID		2624	4781
HPRD ID		00673	09008
Ensembl ID		ENSG00000179348	ENSG00000147862
Uniprot IDs		P23769	A0A0A0MRX8 A0A1B0GU97 A0A1B0GVN4 A0A1B0GW37 A0A1B0GWB8 A0A2R8Y7V8 O00712 Q5VW26 Q5VW27 Q5VW28 Q5VW30 Q5W0Y9 U3KQE8
PDB IDs		5O9B 6ZFV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Negative Regulation Of Developmental Process Chromatin Binding DNA Binding Regulation Of MiRNA Transcription Histone Deacetylase Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Primary Metabolic Process Interleukin-6-mediated Signaling Pathway Identical Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of MiRNA Metabolic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Differentiation Cell Population Proliferation Regulation Of Gene Expression SMAD Protein Signal Transduction	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Negative Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Positive Regulation Of Biosynthetic Process Thyroid-stimulating Hormone-secreting Cell Differentiation Negative Regulation Of Metabolic Process Transcription Coactivator Binding Positive Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Neuron Differentiation Developmental Process
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