NFIB and NHLH1

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		NFIB	NHLH1
Description		nuclear factor I B	nescient helix-loop-helix 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Cerebellar Mossy Fiber	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Tissue Homeostasis Chondrocyte Differentiation Glandular Epithelial Cell Differentiation DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Cell Population Proliferation Response To Wounding Response To Bacterium Glial Cell Differentiation Exit From Mitosis Gene Expression Glial Cell Proliferation Stem Cell Population Maintenance Principal Sensory Nucleus Of Trigeminal Nerve Development Glial Cell Fate Specification Cell Proliferation In Forebrain Anterior Commissure Morphogenesis Neurogenesis Lung Development Forebrain Development Hindbrain Development Regeneration Negative Regulation Of DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Generation Of Neurons Retina Development In Camera-type Eye Club Cell Differentiation Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Salivary Gland Cavitation Cell Differentiation Involved In Salivary Gland Development Lung Ciliated Cell Differentiation Neural Precursor Cell Proliferation Commissural Neuron Axon Guidance Stem Cell Proliferation Negative Regulation Of MiRNA Transcription Negative Regulation Of Stem Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcoholic chronic pancreatitis ( 28754779) Alzheimer's disease biomarkers ( 23419831) Ankle injury ( 28957384) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metastasis at diagnosis in osteosarcoma ( 26084801) Red blood cell count ( 32888494)
Interacting Genes		17 interacting genes: ELK3 ERG ETV7 FOS FOXL1 GATA2 GATA3 KLF16 KLF8 LHX2 LHX3 NFIC NFIX NHLH1 RFX1 SFN TBXT	12 interacting genes: CCT7 CENPP CSRP3 INO80E LMO1 LMO2 LMO4 NFIA NFIB PIM1 PSME2 TCF3
Entrez ID		4781	4807
HPRD ID		09008	01212
Ensembl ID		ENSG00000147862	ENSG00000171786
Uniprot IDs		A0A0A0MRX8 A0A1B0GU97 A0A1B0GVN4 A0A1B0GW37 A0A1B0GWB8 A0A2R8Y7V8 O00712 Q5VW26 Q5VW27 Q5VW28 Q5VW30 Q5W0Y9 U3KQE8	Q02575 Q5T203
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Negative Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Positive Regulation Of Biosynthetic Process Thyroid-stimulating Hormone-secreting Cell Differentiation Negative Regulation Of Metabolic Process Transcription Coactivator Binding Positive Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Neuron Differentiation Developmental Process	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Neuron Fate Specification Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Glial Cell Fate Specification Nucleoplasm Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Exit From Mitosis Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Generation Of Neurons Regulation Of Macromolecule Biosynthetic Process BHLH Transcription Factor Binding Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Positive Regulation Of Cardioblast Proliferation Positive Regulation Of Actin Filament Severing Regulation Of Gene Expression Positive Regulation Of Telomere Maintenance Retina Development In Camera-type Eye DNA Metabolic Process Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Actin Filament Severing Nucleus Regulation Of Multicellular Organismal Process Regulation Of Stem Cell Proliferation Regulation Of T Cell Homeostatic Proliferation Neural Precursor Cell Proliferation Principal Sensory Nucleus Of Trigeminal Nerve Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Activator Complex Vitamin D Response Element Binding Ventral Spinal Cord Interneuron Differentiation Positive Regulation Of Chromosome Organization
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