GATA2 and RXRA

Number of citations of the paper that reports this interaction (PubMedID 15254248)
68

Data Source:
HPRD (in vivo)

		GATA2	RXRA
Description		GATA binding protein 2	retinoid X receptor alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Retinoic Acid Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Peptide Binding Identical Protein Binding Nuclear Vitamin D Receptor Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding DNA Binding Domain Binding LBD Domain Binding Vitamin D Response Element Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Urogenital System Development Cell Fate Determination Neuron Migration Embryonic Placenta Development Glandular Epithelial Cell Differentiation Glandular Epithelial Cell Maturation Hematopoietic Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Phagocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Primitive Erythrocyte Differentiation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Differentiation Central Nervous System Neuron Development Pituitary Gland Development Myeloid Cell Differentiation Cell Differentiation Neuron Differentiation Response To Lipid Somatic Stem Cell Population Maintenance Eosinophil Fate Commitment Inner Ear Morphogenesis Neuron Maturation Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment System Development Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Regulation Of Developmental Process Brown Fat Cell Differentiation Positive Regulation Of Phagocytosis, Engulfment Thyroid-stimulating Hormone-secreting Cell Differentiation Definitive Hemopoiesis Semicircular Canal Development Vascular Wound Healing Neuroendocrine Cell Differentiation Neural Precursor Cell Proliferation Hematopoietic Stem Cell Homeostasis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cochlea Development GABAergic Neuron Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of MiRNA Transcription Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Forebrain Neuron Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of DNA-templated Transcription Nervous System Development Hormone-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Cell Differentiation Monocyte Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Response To Retinoic Acid Peroxisome Proliferator Activated Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Lipid Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Cell Maturation Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Low-density Lipoprotein Particle Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Lipoprotein Transport
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production	BMAL1:CLOCK,NPAS2 activates circadian expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Carnitine shuttle Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Cytoprotection by HMOX1 Heme signaling TGFBR3 expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs			alpha-Linolenic acid Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Etodolac Tretinoin Etretinate Bezafibrate Alfacalcidol Phthalic Acid Doconexent Oleic Acid Arachidonic Acid EVT-101 3,20-Pregnanedione 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Tributyltin
Diseases
GWAS		Basophil count ( 28031487) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) Eosinophil count ( 19198610) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Preterm birth (maternal effect) ( 28877031) Prostate cancer ( 31562322) Pulse pressure ( 30578418 28135244 27841878) Systolic blood pressure ( 27841878) White blood cell count ( 21738480) White blood cell count (basophil) ( 28158719) White blood cell count (eosinophil) ( 28158719) White blood cell types ( 21738478)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Blood pressure ( 24954895) Central corneal thickness ( 22814818 23493294 28171582 29760442 30894546 31798171) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) HDL cholesterol levels in HIV infection ( 33109212) Intelligence ( 22449649) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		49 interacting genes: ADAMTSL4 AKT1 CDK1 CEBPA COP1 CYSRT1 FBXW7 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 KRTAP11-1 KRTAP13-3 KRTAP21-2 KRTAP3-1 KRTAP6-3 KRTAP7-1 KRTAP8-1 LMO2 MAPK1 MDFI MSX2 NFIA NFIB NFIC NOTCH2NLA PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RBPMS RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1	119 interacting genes: ACVR1 ACVR1B ALOX15B ARID5A BCL3 BMAL1 BRD8 CASP2 CHD9 CLOCK CNOT1 COPS2 CSNK2B CTCF CTNNB1 CTSL DNMT3L DNTTIP2 EDF1 ESR1 ESRRA FUS GADD45A GADD45G GATA2 GK GRIP1 GSK3B HDAC3 HDAC4 HMGA1 IGFBP3 ITGB3BP JAZF1 JMJD1C KIF1A KLF5 MAPK1 MAPK3 MAPK7 MECR MED1 MED24 MED25 MPG MYOD1 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NFKB1 NFKBIB NPAS2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2E3 NR2F1 NR2F6 NR3C2 NR4A1 NR4A2 NRBF2 NRIP1 NSD1 PARP1 PLK1 PML POU2F1 POU2F2 PPARA PPARD PPARG PPARGC1A PRKD2 PRMT2 PSMC3IP PSMC5 RAD54L2 RARA RARB RARG RELA RNF8 ROBO4 RPS6KA6 SMAD2 SMARCB1 SMARCD3 SMN1 SNW1 SP1 SRC SRF STAT1 TADA3 TAF11 TAF1B TBP TDG THRA THRB TK1 TMPRSS3 TRIM24 TRIP10 TRIP4 UBE2I UBQLN4 UBR5 VDR ZBTB16 ZNHIT3
Entrez ID		2624	6256
HPRD ID		00673	01577
Ensembl ID		ENSG00000179348	ENSG00000186350
Uniprot IDs		P23769	A0A5F9ZHH6 F1D8Q5 P19793 Q6P3U7
PDB IDs		5O9B 6ZFV	1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6JNO 6JNR 6L6K 6LB4 6LB5 6LB6 6SJM 6STI 6XWG 6XWH 7A77 7B88 7B9O 7BK4 7CFO 7NKE 7UW2 7UW4 8HBM 8PP0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Negative Regulation Of Developmental Process Chromatin Binding DNA Binding Regulation Of MiRNA Transcription Histone Deacetylase Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Primary Metabolic Process Interleukin-6-mediated Signaling Pathway Identical Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of MiRNA Metabolic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Differentiation Cell Population Proliferation Regulation Of Gene Expression SMAD Protein Signal Transduction	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Nuclear Receptor Activity Nuclear Retinoid X Receptor Binding Nuclear Receptor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Sequence-specific DNA Binding Nuclear Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-templated Transcription Transcription Coactivator Activity Transcription By RNA Polymerase II Nuclear Thyroid Hormone Receptor Binding Transcription Regulator Complex Nuclear Retinoic Acid Receptor Binding Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Cellular Response To Hormone Stimulus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?