GATA2 and CYSRT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GATA2	CYSRT1
Description		GATA binding protein 2	cysteine rich tail 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm	Cornified Envelope Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Urogenital System Development Cell Fate Determination Neuron Migration Embryonic Placenta Development Glandular Epithelial Cell Differentiation Glandular Epithelial Cell Maturation Hematopoietic Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Phagocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Primitive Erythrocyte Differentiation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Differentiation Central Nervous System Neuron Development Pituitary Gland Development Myeloid Cell Differentiation Cell Differentiation Neuron Differentiation Response To Lipid Somatic Stem Cell Population Maintenance Eosinophil Fate Commitment Inner Ear Morphogenesis Neuron Maturation Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment System Development Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Regulation Of Developmental Process Brown Fat Cell Differentiation Positive Regulation Of Phagocytosis, Engulfment Thyroid-stimulating Hormone-secreting Cell Differentiation Definitive Hemopoiesis Semicircular Canal Development Vascular Wound Healing Neuroendocrine Cell Differentiation Neural Precursor Cell Proliferation Hematopoietic Stem Cell Homeostasis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cochlea Development GABAergic Neuron Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of MiRNA Transcription Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Forebrain Neuron Differentiation	Biological Process Involved In Interaction With Symbiont Establishment Of Skin Barrier
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Basophil count ( 28031487) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) Eosinophil count ( 19198610) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Preterm birth (maternal effect) ( 28877031) Prostate cancer ( 31562322) Pulse pressure ( 30578418 28135244 27841878) Systolic blood pressure ( 27841878) White blood cell count ( 21738480) White blood cell count (basophil) ( 28158719) White blood cell count (eosinophil) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		49 interacting genes: ADAMTSL4 AKT1 CDK1 CEBPA COP1 CYSRT1 FBXW7 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 KRTAP11-1 KRTAP13-3 KRTAP21-2 KRTAP3-1 KRTAP6-3 KRTAP7-1 KRTAP8-1 LMO2 MAPK1 MDFI MSX2 NFIA NFIB NFIC NOTCH2NLA PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RBPMS RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1	503 interacting genes: A1CF ACTMAP ACY3 ADAM12 ADAMTSL3 ADAMTSL4 ADAMTSL5 AGXT ALDH3B1 ALPP ANAPC11 ANKS1A AQP1 AREG ARHGAP33 ARHGAP9 ARID5A ASTL ATG9A ATOSB ATPAF2 ATXN7L2 AVPI1 B4GALT7 BAG3 BAG6 BAHD1 BAIAP2L1 BEX1 BEX2 BLCAP BMP7 BRME1 BSCL2 C11orf16 C11orf87 C22orf39 CACNA1A CACNA1S CARD10 CARHSP1 CATSPER1 CBLL2 CBX2 CCDC120 CCDC187 CCDC28A-AS1 CCER1 CCNK CD300LG CDKL3 CELF5 CERCAM CERK CES1 CFAP206 CFP CHCHD2 CHCHD3 CHIC2 CHRD CHRNG CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COL8A1 COMP CRCT1 CREB5 CRH CRY2 CRYBA1 CRYBA2 CSF1 CST2 CST9L CTRC CTSG CTSZ CXCL16 CYP21A2 CYP2S1 DACT2 DALRD3 DBF4B DBH DCDC2B DDX43 DLGAP2 DMRT3 DNAJA3 DNASE1L3 DOCK2 DRC4 DVL3 ECE1 ECM1 EEIG1 EFEMP1 EFEMP2 EMC7 ENKD1 EPS8L1 ERH ESR2 ETNK2 FADS6 FAM124B FAM221A FAM221B FAM83A FAM90A1 FARS2 FASLG FBXL9P FBXW5 FEZF1 FHL3 FOXD2 FOXD4L1 FOXD4L3 FOXH1 FRS3 FRZB FZD10 GARIN6 GATA2 GATA3 GATA5 GCSAM GEM GGN GLB1L2 GLP1R GLYAT GNE GNG13 GPANK1 GPATCH2L GPRIN2 GPS2 GRN GSTP1 GUCD1 HBZ HCK HDHD3 HEY2 HHEX HLX HOXA1 HOXB5 HOXB9 HOXC8 HOXC9 HR HRG HSBP1 HSD3B7 HSPA12B HSPD1 HYAL2 HYPK ICAM1 ICAM4 IL16 INCA1 INO80B INPP5D INS INTS5 IQCN IQUB ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KLHL38 KLK8 KPRP KRT20 KRT31 KRT33B KRT34 KRT81 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-3 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 KRTAP9-2 KRTAP9-3 KRTAP9-8 KSR2 LAGE3 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LENG8 LGALS9C LMF2 LMNTD2 LMO3 LMO4 LNX1 LONRF1 LONRF3 LRFN4 LRRC41 LRRN4 LYVE1 MACROH2A1 MAPKBP1 MCRS1 MED25 MELTF MEOX2 MGAT5B MIIP MKRN3 MRPL23 MRPL40 MSRB1 MT1M MTA1 MTNR1A MXD3 MXI1 MYPOP NBPF19 NDUFA9 NDUFAF3 NECTIN2 NECTIN3 NEU2 NEU4 NKD1 NMU NOTCH2NLA NOXA1 NPBWR2 NPDC1 NPPB NR1D2 NR4A3 NSD1 NTAQ1 NTN4 NUBP2 NUFIP2 OLIG3 OR7A17 OTOS OTX1 P2RX7 PATZ1 PCSK5 PDE9A PGAP2 PGAP6 PHETA1 PHLDA1 PITX1 PITX2 PKD2 PKN1 PLA2G10 PLAC8 PLEKHN1 PLLP POU4F2 PPP1CB PPY PRF1 PRKAA2 PRKAB2 PROC PROP1 PRPF31 PRR19 PRR22 PRR30 PRR34 PRR35 PTGDS PTK7 PTPMT1 PVR QRICH1 R3HDM2 RAB3IL1 RALGDS RAMAC RAMP3 RASD1 RBM22 RBP3 RECK REM2 RGL2 RGS3 RHBG RHNO1 RNF38 RPS19BP1 RPUSD3 RSPO2 RTN4RL1 SAPCD2 SAXO1 SAXO4 SAXO5 SCARF1 SCNM1 SEMA3B SEMA4C SH3KBP1 SH3RF2 SHFL SHISA6 SLC12A4 SLC13A5 SLC23A1 SLC25A18 SLC25A48 SLC43A2 SLC5A5 SLC68A1 SLC6A20 SLIT1 SMARCC1 SMARCD1 SMARCE1 SMCP SMOC1 SMUG1 SNRPB SNRPC SNX18 SOCS7 SPATA24 SPATA3 SPATA46 SPATA8 SPEF1 SPG7 SPMIP2 SPMIP4 SPMIP6 SPMIP9 SPON1 SPPL2C SPRY1 SPTSSA SRD5A2 SSC4D STK16 TAPBPL TBX2 TBX6 TCAF1 TCEA2 TCEANC TCF7L2 TENT5B TEPSIN TFAP2D TGFB1 THAP7 TIMM22 TLE5 TM7SF2 TMEM174 TNIP1 TNIP3 TNK2 TNS4 TRAPPC14 TREX1 TRIM42 TSGA10IP TSPAN4 TTC23 TTPA TYK2 UBXN7 USP54 UTP23 VASN VENTX VGLL3 VSTM4 VWC2 VWC2L WDR25 WIF1 WNT11 WT1 YPEL3 YY1 ZBTB25 ZBTB4 ZCCHC14 ZDHHC1 ZFHX2 ZIC1 ZMYND10 ZNF124 ZNF266 ZNF319 ZNF330 ZNF34 ZNF408 ZNF414 ZNF417 ZNF419 ZNF438 ZNF439 ZNF440 ZNF441 ZNF446 ZNF497 ZNF552 ZNF575 ZNF580 ZNF581 ZNF587 ZNF648 ZNF669 ZNF683 ZNF696 ZNF764 ZNF775 ZNF786 ZNF835 ZNF837 ZNF843 ZNHIT1 ZSCAN5A
Entrez ID		2624	375791
HPRD ID		00673	14696
Ensembl ID		ENSG00000179348	ENSG00000197191
Uniprot IDs		P23769	A8MQ03
PDB IDs		5O9B 6ZFV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Negative Regulation Of Developmental Process Chromatin Binding DNA Binding Regulation Of MiRNA Transcription Histone Deacetylase Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Primary Metabolic Process Interleukin-6-mediated Signaling Pathway Identical Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of MiRNA Metabolic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Differentiation Cell Population Proliferation Regulation Of Gene Expression SMAD Protein Signal Transduction	Intermediate Filament Protein Binding Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Animal Organ Morphogenesis DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Structural Constituent Of Skin Epidermis
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