GATA2 and POU2AF1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		GATA2	POU2AF1
Gene Name		GATA binding protein 2	POU class 2 associating factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Protein Complex	Nucleus
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Enhancer Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding C2H2 Zinc Finger Domain Binding	DNA Binding Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Urogenital System Development Cell Fate Determination Embryonic Placenta Development Transcription, DNA-templated Phagocytosis Blood Coagulation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Pituitary Gland Development Somatic Stem Cell Maintenance Regulation Of Histone Acetylation Eosinophil Fate Commitment Inner Ear Morphogenesis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Definitive Hemopoiesis Semicircular Canal Development Negative Regulation Of Fat Cell Proliferation GABAergic Neuron Differentiation Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Forebrain Neuron Differentiation	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Humoral Immune Response
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Eosinophil counts ( 19198610) White blood cell count ( 21738480) White blood cell types ( 21738478)	Corneal structure ( 23291589) Primary biliary cirrhosis ( 23000144)
Protein-Protein Interactions		34 interactors: ADAMTSL4 AKT1 CEBPA EP300 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 LMO2 MAPK1 MDFI NOTCH2NL PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1	16 interactors: GATA2 GTF2H1 GTF2I MSX2 NAB1 PAX8 POU2F1 POU2F2 RHOXF2 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK
Entrez ID		2624	5450
HPRD ID		00673	03126
Ensembl ID		ENSG00000179348	ENSG00000110777
Uniprot IDs		P23769	Q16633
PDB IDs			1CQT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Organ Development Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Hemopoiesis Immune System Development Embryo Development System Development Multicellular Organismal Development Biosynthetic Process Immune System Process Cellular Nitrogen Compound Metabolic Process Cardiovascular System Development Gland Development Regulation Of Metabolic Process Myeloid Cell Differentiation Regulation Of Binding Developmental Process Anatomical Structure Development Nitrogen Compound Metabolic Process Regulation Of Cell Differentiation Protein Localization To Nucleus Regulation Of Myeloid Cell Differentiation Nucleobase-containing Compound Metabolic Process Tissue Development	Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Organ Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Anatomical Structure Morphogenesis RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Differentiation Ammonium Transport Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Quaternary Ammonium Group Transport Negative Regulation Of RNA Biosynthetic Process System Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Monoamine Transport Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Stimulus Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Drug Transmembrane Transport Signal Transduction Involved In Regulation Of Gene Expression Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Secretion By Cell Organ Development Positive Regulation Of BMP Signaling Pathway Anatomical Structure Development Ammonium Transmembrane Transport
Tagcloud ?		arises begins betah1 commitment conceptus conceptuses e7 e8 ectodermal erythroblasts erythropoiesis extraembryonic gastrulation globin headfold islands mesoderm morphologically ordered primitive proceeds rbtn2 recognizable sac somite streak vys yolk
Tagcloud (Difference) ?		arises begins betah1 commitment conceptus conceptuses e7 e8 ectodermal erythroblasts erythropoiesis extraembryonic gastrulation globin headfold islands mesoderm morphologically ordered primitive proceeds rbtn2 recognizable sac somite streak vys yolk
Tagcloud (Intersection) ?