NFIB and TBXT

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (proximity labelling technology, pull down)

		NFIB	TBXT
Description		nuclear factor I B	T-box transcription factor T
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Cerebellar Mossy Fiber	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Tissue Homeostasis Chondrocyte Differentiation Glandular Epithelial Cell Differentiation DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Cell Population Proliferation Response To Wounding Response To Bacterium Glial Cell Differentiation Exit From Mitosis Gene Expression Glial Cell Proliferation Stem Cell Population Maintenance Principal Sensory Nucleus Of Trigeminal Nerve Development Glial Cell Fate Specification Cell Proliferation In Forebrain Anterior Commissure Morphogenesis Neurogenesis Lung Development Forebrain Development Hindbrain Development Regeneration Negative Regulation Of DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Generation Of Neurons Retina Development In Camera-type Eye Club Cell Differentiation Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Salivary Gland Cavitation Cell Differentiation Involved In Salivary Gland Development Lung Ciliated Cell Differentiation Neural Precursor Cell Proliferation Commissural Neuron Axon Guidance Stem Cell Proliferation Negative Regulation Of MiRNA Transcription Negative Regulation Of Stem Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Somitogenesis Heart Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Mesoderm Development Anterior/posterior Axis Specification, Embryo Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Cell Myoblast Differentiation Primitive Streak Formation
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	Cardiogenesis Germ layer formation at gastrulation Epithelial-Mesenchymal Transition (EMT) during gastrulation Formation of paraxial mesoderm Formation of axial mesoderm Formation of definitive endoderm
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcoholic chronic pancreatitis ( 28754779) Alzheimer's disease biomarkers ( 23419831) Ankle injury ( 28957384) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metastasis at diagnosis in osteosarcoma ( 26084801) Red blood cell count ( 32888494)
Interacting Genes		17 interacting genes: ELK3 ERG ETV7 FOS FOXL1 GATA2 GATA3 KLF16 KLF8 LHX2 LHX3 NFIC NFIX NHLH1 RFX1 SFN TBXT	3 interacting genes: NFIA NFIB NFIC
Entrez ID		4781	6862
HPRD ID		09008	03236
Ensembl ID		ENSG00000147862	ENSG00000164458
Uniprot IDs		A0A0A0MRX8 A0A1B0GU97 A0A1B0GVN4 A0A1B0GW37 A0A1B0GWB8 A0A2R8Y7V8 O00712 Q5VW26 Q5VW27 Q5VW28 Q5VW30 Q5W0Y9 U3KQE8	J3KP65 O15178
PDB IDs			5QRF 5QRG 5QRH 5QRI 5QRJ 5QRK 5QRL 5QRM 5QRN 5QRO 5QRP 5QRQ 5QRR 5QRS 5QRT 5QRU 5QRV 5QRW 5QRX 5QRY 5QRZ 5QS0 5QS1 5QS2 5QS3 5QS4 5QS5 5QS6 5QS7 5QS8 5QS9 5QSA 5QSB 5QSC 5QSD 5QSE 5QSF 5QSG 5QSH 5QSI 5QSJ 5QSK 5QSL 5QT0 6F58 6F59 6ZU8 7HI8 7HI9 7ZK2 7ZKF 7ZL2 8A10 8A7N 8CDN 8FMU
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Negative Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Positive Regulation Of Biosynthetic Process Thyroid-stimulating Hormone-secreting Cell Differentiation Negative Regulation Of Metabolic Process Transcription Coactivator Binding Positive Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Neuron Differentiation Developmental Process	Glial Cell Fate Specification DNA Replication Exit From Mitosis Generation Of Neurons Neuron Fate Specification Glial Cell Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Retina Development In Camera-type Eye Cell Fate Specification DNA-binding Transcription Factor Activity Neural Precursor Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Neurogenesis DNA Metabolic Process Double-stranded DNA Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Involved In Salivary Gland Development Fibrillar Center Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Brain Renin-angiotensin System Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Principal Sensory Nucleus Of Trigeminal Nerve Development Developmental Maturation Chromatin Response To Wounding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Club Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Salivary Gland Cavitation Anterior Commissure Morphogenesis Ribosomal Protein S6 Kinase Activity Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Transcription By RNA Polymerase II Ureter Development Positive Regulation Of Metabolic Process Gene Expression Multi-ciliated Epithelial Cell Differentiation Type II Pneumocyte Differentiation Cerebellar Mossy Fiber Negative Regulation Of Mesenchymal Cell Proliferation Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Animal Organ Development Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Type I Pneumocyte Differentiation Negative Regulation Of Meiotic Nuclear Division Macromolecule Biosynthetic Process
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