GATA2 and STAT3

Number of citations of the paper that reports this interaction (PMID 15673499)
7

Data Source:
HPRD (in vitro, in vivo)

		GATA2	STAT3
Gene Name		GATA binding protein 2	signal transducer and activator of transcription 3 (acute-phase response factor)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Protein Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Enhancer Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding CCR5 Chemokine Receptor Binding Glucocorticoid Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Urogenital System Development Cell Fate Determination Embryonic Placenta Development Transcription, DNA-templated Phagocytosis Blood Coagulation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Pituitary Gland Development Somatic Stem Cell Maintenance Regulation Of Histone Acetylation Eosinophil Fate Commitment Inner Ear Morphogenesis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Definitive Hemopoiesis Semicircular Canal Development Negative Regulation Of Fat Cell Proliferation GABAergic Neuron Differentiation Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Forebrain Neuron Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Import Into Nucleus Movement Of Cell Or Subcellular Component Acute-phase Response Signal Transduction JAK-STAT Cascade Nervous System Development Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Intracellular Receptor Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Somatic Stem Cell Maintenance Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Eating Behavior Response To Ethanol Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Astrocyte Differentiation Radial Glial Cell Differentiation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of Cell Death Interleukin-6-mediated Signaling Pathway Negative Regulation Of Neuron Migration
Pathways		Factors involved in megakaryocyte development and platelet production	Signaling by PDGF Signalling by NGF Signaling by FGFR in disease Cellular Senescence Interleukin-6 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by SCF-KIT Signaling by Interleukins Transcriptional regulation of pluripotent stem cells Downstream signal transduction Signaling by FGFR1 mutants Signalling to STAT3 Signaling by FGFR mutants Signaling by FGFR1 fusion mutants POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by Leptin Growth hormone receptor signaling
Drugs
Diseases
GWAS		Eosinophil counts ( 19198610) White blood cell count ( 21738480) White blood cell types ( 21738478)	Crohn's disease ( 18587394 21102463 23266558) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 21833088 20159113)
Protein-Protein Interactions		34 interactors: ADAMTSL4 AKT1 CEBPA EP300 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 LMO2 MAPK1 MDFI NOTCH2NL PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1	161 interactors: ADRB2 AMBP AR ARFIP2 ASXL1 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 CAPN1 CAPNS1 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBB2IP FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GATA1 GATA2 GHR GNB2L1 GNL3 GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HIC1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KPNA1 KPNA6 LAMB2 LCK LEP LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MET MORC4 MRPS31 MTOR MYOD1 NCOA1 NDUFA13 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 OGDHL PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PML PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RAC1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 SCAF11 SETD7 SIAH1 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 SSSCA1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TRIM28 TRIP10 TSHR TSLP ZFPM2 ZNF148 ZNF467
Entrez ID		2624	6774
HPRD ID		00673	00026
Ensembl ID		ENSG00000179348	ENSG00000168610
Uniprot IDs		P23769	K7ENL3 P40763
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Organ Development Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Hemopoiesis Immune System Development Embryo Development System Development Multicellular Organismal Development Biosynthetic Process Immune System Process Cellular Nitrogen Compound Metabolic Process Cardiovascular System Development Gland Development Regulation Of Metabolic Process Myeloid Cell Differentiation Regulation Of Binding Developmental Process Anatomical Structure Development Nitrogen Compound Metabolic Process Regulation Of Cell Differentiation Protein Localization To Nucleus Regulation Of Myeloid Cell Differentiation Nucleobase-containing Compound Metabolic Process Tissue Development	Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Defense Response Response To Cytokine Regulation Of Signal Transduction Immune System Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Communication Signaling Positive Regulation Of Gene Expression Response To Stress Response To Stimulus Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Regulation Of Immune Response Immune Response Protein Autophosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Positive Regulation Of Cell Proliferation Positive Regulation Of Immune System Process Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Response To External Stimulus Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation
Tagcloud ?		arises begins betah1 commitment conceptus conceptuses e7 e8 ectodermal erythroblasts erythropoiesis extraembryonic gastrulation globin headfold islands mesoderm morphologically ordered primitive proceeds rbtn2 recognizable sac somite streak vys yolk	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Difference) ?		arises begins betah1 commitment conceptus conceptuses e7 e8 ectodermal erythroblasts erythropoiesis extraembryonic gastrulation globin headfold islands mesoderm morphologically ordered primitive proceeds rbtn2 recognizable sac somite streak vys yolk	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Intersection) ?