NFIB and KLF8

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		NFIB	KLF8
Description		nuclear factor I B	KLF transcription factor 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Cerebellar Mossy Fiber	Chromatin Nucleus Nucleoplasm Cytosol Aggresome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Tissue Homeostasis Chondrocyte Differentiation Glandular Epithelial Cell Differentiation DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Cell Population Proliferation Response To Wounding Response To Bacterium Glial Cell Differentiation Exit From Mitosis Gene Expression Glial Cell Proliferation Stem Cell Population Maintenance Principal Sensory Nucleus Of Trigeminal Nerve Development Glial Cell Fate Specification Cell Proliferation In Forebrain Anterior Commissure Morphogenesis Neurogenesis Lung Development Forebrain Development Hindbrain Development Regeneration Negative Regulation Of DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Generation Of Neurons Retina Development In Camera-type Eye Club Cell Differentiation Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Salivary Gland Cavitation Cell Differentiation Involved In Salivary Gland Development Lung Ciliated Cell Differentiation Neural Precursor Cell Proliferation Commissural Neuron Axon Guidance Stem Cell Proliferation Negative Regulation Of MiRNA Transcription Negative Regulation Of Stem Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcoholic chronic pancreatitis ( 28754779) Alzheimer's disease biomarkers ( 23419831) Ankle injury ( 28957384) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metastasis at diagnosis in osteosarcoma ( 26084801) Red blood cell count ( 32888494)	Blood trace element (Zn levels) ( 23720494) Male-pattern baldness ( 27182965 28196072)
Interacting Genes		17 interacting genes: ELK3 ERG ETV7 FOS FOXL1 GATA2 GATA3 KLF16 KLF8 LHX2 LHX3 NFIC NFIX NHLH1 RFX1 SFN TBXT	6 interacting genes: APP CTBP2 FHL3 NFIA NFIB NFIC
Entrez ID		4781	11279
HPRD ID		09008	02238
Ensembl ID		ENSG00000147862	ENSG00000102349
Uniprot IDs		A0A0A0MRX8 A0A1B0GU97 A0A1B0GVN4 A0A1B0GW37 A0A1B0GWB8 A0A2R8Y7V8 O00712 Q5VW26 Q5VW27 Q5VW28 Q5VW30 Q5W0Y9 U3KQE8	O95600 Q05BZ3
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cellular Developmental Process Negative Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Positive Regulation Of Biosynthetic Process Thyroid-stimulating Hormone-secreting Cell Differentiation Negative Regulation Of Metabolic Process Transcription Coactivator Binding Positive Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Neuron Differentiation Developmental Process	Glial Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II DNA Replication Exit From Mitosis Viral Genome Replication Generation Of Neurons Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of MiRNA Transcription Positive Regulation Of DNA-templated Transcription Neuron Fate Specification Glial Cell Proliferation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Amylin Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Retina Development In Camera-type Eye DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Fate Specification Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation Positive Regulation Of Biosynthetic Process Acetylcholine Receptor Activator Activity Anatomical Structure Morphogenesis Negative Regulation Of RNA Metabolic Process Lipoprotein Particle Developmental Process Positive Regulation Of Protein Import Neurogenesis Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Positive Regulation Of Macromolecule Metabolic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production
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