UFD1L and GZMK

Number of citations of the paper that reports this interaction (PMID 20876349)
7

Data Source:
BioGRID (enzymatic study)

		UFD1L	GZMK
Gene Name		ubiquitin fusion degradation 1 like (yeast)	granzyme K (granzyme 3; tryptase II)
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Extracellular Region
	Molecular Function	Ubiquitin-specific Protease Activity Receptor Binding Protein Binding Protein Complex Binding	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Proteolysis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: A2M AMFR ANAPC2 F13A1 GZMK IGHM MASP1 NEDD8 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBXN6 VCP	12 interactors: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TUBB3 UFD1L VCP
Entrez ID		7353	3003
HPRD ID		06778	02872
Ensembl ID		ENSG00000070010
Uniprot IDs		Q541A5 Q92890	P49863
PDB IDs		2YUJ	1MZA 1MZD
Enriched GO Terms of Interacting Partners?		Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Complement Activation ER-nucleus Signaling Pathway Response To Growth Factor Regulation Of Fibroblast Apoptotic Process Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Response To Endoplasmic Reticulum Stress Blood Coagulation Hemostasis Regulation Of Complement Activation Cellular Response To Organic Substance Response To Organic Substance Platelet Activation Regulation Of Proteasomal Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Neurotrophin TRK Receptor Signaling Pathway Vesicle-mediated Transport Neurotrophin Signaling Pathway Regulation Of Humoral Immune Response Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Body Fluid Levels Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Positive Regulation Of Cell Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process	Cellular Macromolecule Catabolic Process DNA Metabolic Process DNA Repair DNA Replication DNA Ligation Involved In DNA Repair Nucleotide-excision Repair DNA-dependent DNA Replication DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus DNA Catabolic Process Double-strand Break Repair V(D)J Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process DNA Recombination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Organelle Organization Cell Cycle Mitotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Base-excision Repair DNA Ligation Involved In DNA Recombination Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Stress DNA Catabolic Process, Endonucleolytic Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Polynucleotide 3' Dephosphorylation Chromosome Organization Protein Complex Assembly Aromatic Compound Catabolic Process DNA Biosynthetic Process Cellular Component Assembly Nucleosome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Chromatin Assembly Proteolysis Involved In Cellular Protein Catabolic Process Nucleosome Organization Cellular Protein Catabolic Process Base-excision Repair, DNA Ligation Retrograde Protein Transport, ER To Cytosol Chromatin Assembly Or Disassembly Regulation Of Protein Deubiquitination Lagging Strand Elongation
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