UFD1 and GZMK

Number of citations: 0 (PubMedID 20876349)
Data Source: BioGRID (enzymatic study)

		UFD1	GZMK
Name		ubiquitin recognition factor in ER associated degradation 1	granzyme K
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex	Extracellular Region Extracellular Space Symbiont Cell Surface
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding	Serine-type Endopeptidase Activity Protein Binding Glycosaminoglycan Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Pattern Recognition Receptor Activity
	Biological Process	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production ERAD Pathway Negative Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein	Activation Of Membrane Attack Complex Proteolysis Complement Activation Opsonization Zymogen Activation Killing Of Cells Of Another Organism Positive Regulation Of Inflammatory Response Protein Maturation Positive Regulation Of Release Of Cytochrome C From Mitochondria Granzyme-mediated Programmed Cell Death Signaling Pathway Complement Activation, GZMK Pathway
Pathways		Translesion Synthesis by POLH Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	None
GWAS		No GWAS studies recorded	Blood protein levels ( 30072576 )
Interacting Genes		23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TMUB1 TP53 UBC VCP	13 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TMBIM6 TUBB3 UFD1 VCP
Entrez ID		7353	3003
HPRD ID		06778	02872
Ensembl ID		ENSG00000070010	ENSG00000113088
Uniprot IDs		Q541A5 Q92890	P49863
PDB IDs		2YUJ 5B6C 5C1B 7WWQ	1MZA 1MZD
GO Terms Enriched among Interactors		Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Intracellular Signaling Cassette BAT3 Complex Binding ERAD Pathway Intracellular Protein Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Macroautophagy Protein Metabolic Process Growth Cone Proteasomal Protein Catabolic Process Cytosol Macromolecule Catabolic Process Derlin-1 Retrotranslocation Complex Protein Transport VCP-NPL4-UFD1 AAA ATPase Complex Ubiquitin-dependent Protein Catabolic Process K48-linked Polyubiquitin Modification-dependent Protein Binding Catabolic Process Intracellular Transport Activation Of Membrane Attack Complex Protein Catabolic Process Negative Regulation Of Complement Activation Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Regulation Of Immune Response Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Opsonization Retrograde Protein Transport, ER To Cytosol Macromolecule Metabolic Process Intracellular Protein Localization Ubiquitin-specific Protease Binding Symbiont Cell Surface Intracellular Signal Transduction Regulation Of Fibroblast Apoptotic Process Ubiquitin Binding Negative Regulation Of Autophagy Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Small GTPase-mediated Signal Transduction Regulation Of Complement Activation MAP Kinase Kinase Kinase Activity Extracellular Space Regulation Of Mitochondrion Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Localization Blood Microparticle	VCP-NPL4-UFD1 AAA ATPase Complex K48-linked Polyubiquitin Modification-dependent Protein Binding Retrograde Protein Transport, ER To Cytosol UFD1-NPL4 Complex Cellular Response To Topologically Incorrect Protein Protein Exit From Endoplasmic Reticulum Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of RIG-I Signaling Pathway Damaged DNA Binding Double-strand Break Repair Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process DNA Repair Cellular Response To Misfolded Protein Regulation Of Programmed Cell Death Response To Misfolded Protein ERAD Pathway Base-excision Repair, Gap-filling Nucleus Ubiquitin Protein Ligase Binding V(D)J Recombination Regulation Of RIG-I Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Macromolecule Metabolic Process Organelle Organization DNA Damage Response Negative Regulation Of RNA Splicing Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Apoptotic Process Condensed Chromosome Regulation Of Metabolic Process Base-excision Repair Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Somatic Cell DNA Recombination Negative Regulation Of Type I Interferon Production Negative Regulation Of Biosynthetic Process Protein Domain Specific Binding Basal Body Patch Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To Stress Telomere Maintenance Via Base-excision Repair