TIPRL and PPP2CB

Number of citations of the paper that reports this interaction (PubMedID 26344197)
49

Data Source:
BioGRID (biochemical, affinity chromatography technology, pull down)

		TIPRL	PPP2CB
Description		TOR signaling pathway regulator	protein phosphatase 2 catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Activator Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Transmembrane Transporter Binding Metal Ion Binding Tau Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling TOR Signaling	Mitotic Cell Cycle Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Microtubule Polymerization Response To Endoplasmic Reticulum Stress Response To Hydrogen Peroxide Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic Regulation Of Neurofibrillary Tangle Assembly
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling
Drugs			Vitamin E
Diseases
GWAS		LDL cholesterol levels in HIV infection ( 33109212) Red cell distribution width ( 32888494)	Daytime sleep phenotypes ( 27126917) Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		6 interacting genes: APP CEBPA PPP2CB PPP4C PPP6C UFL1	41 interacting genes: ACP5 AXIN1 BHLHE41 BUB1 C22orf39 DOCK7 DYNLT2B EGFR GAD1 GSTA1 HK3 KRAS LCMT1 MAK MAPT MID1 MLH1 MLH3 NRAS PACS1 PDGFRL PLXNA3 PMS2 PRKCB PTPRJ RAF1 RELA RPLP1 SGO1 SMAD4 SRC STK11 TAB1 TAB2 TGFBR2 TIPRL TLX1 TRMT61B UBC ZFP28 ZNF775
Entrez ID		261726	5516
HPRD ID		14608	01487
Ensembl ID		ENSG00000143155	ENSG00000104695
Uniprot IDs		O75663	A0A140VJS0 P62714
PDB IDs		5D9G
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Phosphatase Activity Phosphoprotein Phosphatase Activity Response To Lead Ion Positive Regulation Of Proteolysis Response To Stress Regulation Of Defense Response Positive Regulation Of Immune System Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Metal Ion Positive Regulation Of Cell Activation Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response Positive Regulation Of Defense Response RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding UFM1 Ligase Activity Protein Dephosphorylation Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Immune System Process Regulation Of Cell Activation Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Defense Response Macromolecule Metabolic Process Lipoprotein Particle Memory Regulation Of Cellular Response To Stress Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Immune System Process CHOP-C/EBP Complex Cellular Response To Stress	Intracellular Signal Transduction Mismatch Repair Complex Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Response To Growth Factor MAPK Cascade Kinase Activity Mismatched DNA Binding Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Enzyme Binding Chiasma Intracellular Signaling Cassette Positive Regulation Of Multicellular Organismal Process Cytosol Regulation Of Multicellular Organismal Process ATP-dependent DNA Damage Sensor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade MutLalpha Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Protein Phosphorylation ATP Binding Immune Response-activating Signaling Pathway Regulation Of Neurogenesis Regulation Of MAPK Cascade Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Morphogenesis Of A Branching Epithelium Positive Regulation Of Immune Response Positive Regulation Of Protein Modification Process Animal Organ Morphogenesis Anatomical Structure Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Developmental Process Phosphorylation Gland Morphogenesis Morphogenesis Of A Branching Structure Mismatch Repair Cell Development Nucleotide Binding Negative Regulation Of Cellular Component Organization Transferase Activity
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