TIPRL and PPP6C

Number of citations of the paper that reports this interaction (PubMedID 36652389)
40

Data Source:
BioGRID (affinity chromatography technology, pull down, cross-linking study, affinity chromatography technology)

		TIPRL	PPP6C
Description		TOR signaling pathway regulator	protein phosphatase 6 catalytic subunit
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Activator Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	DNA Damage Checkpoint Signaling TOR Signaling	G1/S Transition Of Mitotic Cell Cycle Immune System Process Protein Dephosphorylation Innate Immune Response COPII Vesicle Coating CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway
Pathways			Telomere Extension By Telomerase COPII-mediated vesicle transport
Drugs
Diseases
GWAS		LDL cholesterol levels in HIV infection ( 33109212) Red cell distribution width ( 32888494)	Pulse pressure ( 27841878) Refractive error ( 32231278) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		6 interacting genes: APP CEBPA PPP2CB PPP4C PPP6C UFL1	7 interacting genes: AURKA IGBP1 NFKBIE TGFBR1 TIPRL VAC14 ZNRF2
Entrez ID		261726	5537
HPRD ID		14608	02141
Ensembl ID		ENSG00000143155	ENSG00000119414
Uniprot IDs		O75663	A0A024R861 O00743
PDB IDs		5D9G
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Phosphatase Activity Phosphoprotein Phosphatase Activity Response To Lead Ion Positive Regulation Of Proteolysis Response To Stress Regulation Of Defense Response Positive Regulation Of Immune System Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Metal Ion Positive Regulation Of Cell Activation Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response Positive Regulation Of Defense Response RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding UFM1 Ligase Activity Protein Dephosphorylation Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Immune System Process Regulation Of Cell Activation Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Defense Response Macromolecule Metabolic Process Lipoprotein Particle Memory Regulation Of Cellular Response To Stress Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Immune System Process CHOP-C/EBP Complex Cellular Response To Stress	Peptidyl-serine Phosphorylation
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