TIPRL and UFL1

Number of citations of the paper that reports this interaction (PubMedID 32545848)
54

Data Source:
BioGRID (two hybrid)

		TIPRL	UFL1
Description		TOR signaling pathway regulator	UFM1 specific ligase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Chromosome Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex Site Of Double-strand Break Neuron Projection
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Activator Activity	Protein Binding Transferase Activity Protein Kinase Binding UFM1 Ligase Activity UFM1 Transferase Activity
	Biological Process	DNA Damage Checkpoint Signaling TOR Signaling	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Osteoblast Differentiation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Repair DNA Damage Response Blood Circulation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Autophagy Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Protein Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Regulation Of Inflammatory Response Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Hematopoietic Stem Cell Differentiation Positive Regulation Of Glial Cell Proliferation Reticulophagy Protein Ufmylation Rescue Of Stalled Ribosome Antiviral Innate Immune Response Positive Regulation Of Reticulophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Response To L-glutamate Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of IRE1-mediated Unfolded Protein Response Protein K69-linked Ufmylation
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		LDL cholesterol levels in HIV infection ( 33109212) Red cell distribution width ( 32888494)	Diastolic blood pressure ( 27841878) Headache ( 29397368) Language functional connectivity ( 34929384) Migraine ( 27322543) Migraine without aura ( 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Walking pace ( 33128006)
Interacting Genes		6 interacting genes: APP CEBPA PPP2CB PPP4C PPP6C UFL1	17 interacting genes: AHCY AKAP17A ATP4A ENY2 FGB H2AC4 HINFP IRAK1BP1 IRF3 MT1M PPIL1 PTPRO TIPRL TP53 TSC22D3 UFC1 ZNF219
Entrez ID		261726	23376
HPRD ID		14608	11109
Ensembl ID		ENSG00000143155	ENSG00000014123
Uniprot IDs		O75663	O94874
PDB IDs		5D9G	8B9X 8C0D 8OHD 8OJ0 8OJ5 8OJ8 8QFC 8QFD
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Phosphatase Activity Phosphoprotein Phosphatase Activity Response To Lead Ion Positive Regulation Of Proteolysis Response To Stress Regulation Of Defense Response Positive Regulation Of Immune System Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Metal Ion Positive Regulation Of Cell Activation Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response Positive Regulation Of Defense Response RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding UFM1 Ligase Activity Protein Dephosphorylation Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Immune System Process Regulation Of Cell Activation Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Defense Response Macromolecule Metabolic Process Lipoprotein Particle Memory Regulation Of Cellular Response To Stress Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Immune System Process CHOP-C/EBP Complex Cellular Response To Stress
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