TDG and DNMT3B

Number of citations of the paper that reports this interaction (PubMedID 18452947)
56

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TDG	DNMT3B
Description		thymine DNA glycosylase	DNA methyltransferase 3 beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane PML Body	Nucleus Nucleoplasm Catalytic Complex
	Molecular Function	Magnesium Ion Binding Mismatch Base Pair DNA N-glycosylase Activity Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Transcription Coregulator Activity Uracil DNA N-glycosylase Activity Protein Kinase C Binding Protein Binding ATP Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Hydrolase Activity DNA N-glycosylase Activity Protein Domain Specific Binding Mismatched DNA Binding Sodium Ion Binding Chloride Ion Binding SUMO Binding G/U Mismatch-specific Uracil-DNA Glycosylase Activity DNA-binding Transcription Factor Binding G/T Mismatch-specific Thymine-DNA Glycosylase Activity	DNA Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Chromatin Organization DNA Damage Response Epigenetic Regulation Of Gene Expression Depyrimidination Regulation Of Embryonic Development Chromosomal 5-methylcytosine DNA Demethylation, Oxidation Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 SUMOylation of DNA damage response and repair proteins TET1,2,3 and TDG demethylate DNA	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis
Drugs			Decitabine
Diseases			Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Metabolite levels ( 23823483)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)
Interacting Genes		38 interacting genes: AR CREBBP CRK DDX39B DNMT3B DTL EP300 EPM2A ESR1 HUS1 IKZF1 JUN JUNB MX1 NKX2-1 NR3C1 PCNA PGR PML RAD1 RAD23B RAD51 RAD9A RXRA SERBP1 SETX SIRT6 SKIL SMAD4 SNIP1 STAT3 SUMO1 SUMO2 SUMO3 THRA UBE2I VDR XPC	39 interacting genes: BAZ2A BUD23 CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18
Entrez ID		6996	1789
HPRD ID		03251	04209
Ensembl ID		ENSG00000139372	ENSG00000088305
Uniprot IDs		B4DI29 B4E127 G8JL98 Q13569	A0A8Q3SIG2 Q9UBC3
PDB IDs		1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17	3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91 7O45 7V0E 7X9D 8EIH 8EII 8EIJ 8EIK 8XEE
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Nucleic Acid Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Enzyme Binding Regulation Of Macromolecule Metabolic Process DNA Damage Response Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Transcription Regulator Complex Damaged DNA Binding Rhythmic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Metabolic Process DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Reproductive Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Hormone-mediated Signaling Pathway Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Transcription Coactivator Binding Response To UV Response To Radiation	Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Pericentric Heterochromatin Constitutive Heterochromatin Formation Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Silencing Complex Negative Regulation Of RNA Metabolic Process Facultative Heterochromatin Formation Epigenetic Programming Of Gene Expression Nucleoplasm Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Negative Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Regulation Of Gene Expression RDNA Heterochromatin Formation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Process Chromosome, Centromeric Region Regulation Of Macromolecule Metabolic Process Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Chromosome, Telomeric Region Epigenetic Programming In The Zygotic Pronuclei Regulation Of Chromosome Condensation Regulation Of Primary Metabolic Process Chromosomal DNA Methylation Maintenance Following DNA Replication Condensed Nuclear Chromosome Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity NoRC Complex Methylation
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