TDG and RAD1

Number of citations of the paper that reports this interaction (PubMedID 17855402)
85

Data Source:
BioGRID (pull down)

		TDG	RAD1
Description		thymine DNA glycosylase	RAD1 checkpoint DNA exonuclease
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane PML Body	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex
	Molecular Function	Magnesium Ion Binding Mismatch Base Pair DNA N-glycosylase Activity Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Transcription Coregulator Activity Uracil DNA N-glycosylase Activity Protein Kinase C Binding Protein Binding ATP Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Hydrolase Activity DNA N-glycosylase Activity Protein Domain Specific Binding Mismatched DNA Binding Sodium Ion Binding Chloride Ion Binding SUMO Binding G/U Mismatch-specific Uracil-DNA Glycosylase Activity DNA-binding Transcription Factor Binding G/T Mismatch-specific Thymine-DNA Glycosylase Activity	Damaged DNA Binding Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Chromatin Organization DNA Damage Response Epigenetic Regulation Of Gene Expression Depyrimidination Regulation Of Embryonic Development Chromosomal 5-methylcytosine DNA Demethylation, Oxidation Pathway	DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Substantia Nigra Development Meiotic Recombination Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 SUMOylation of DNA damage response and repair proteins TET1,2,3 and TDG demethylate DNA	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Metabolite levels ( 23823483)	Daytime sleep phenotypes ( 27126917)
Interacting Genes		38 interacting genes: AR CREBBP CRK DDX39B DNMT3B DTL EP300 EPM2A ESR1 HUS1 IKZF1 JUN JUNB MX1 NKX2-1 NR3C1 PCNA PGR PML RAD1 RAD23B RAD51 RAD9A RXRA SERBP1 SETX SIRT6 SKIL SMAD4 SNIP1 STAT3 SUMO1 SUMO2 SUMO3 THRA UBE2I VDR XPC	24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN
Entrez ID		6996	5810
HPRD ID		03251	04400
Ensembl ID		ENSG00000139372	ENSG00000113456
Uniprot IDs		B4DI29 B4E127 G8JL98 Q13569	O60671
PDB IDs		1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17	3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Nucleic Acid Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Enzyme Binding Regulation Of Macromolecule Metabolic Process DNA Damage Response Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Transcription Regulator Complex Damaged DNA Binding Rhythmic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Metabolic Process DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Reproductive Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Hormone-mediated Signaling Pathway Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Transcription Coactivator Binding Response To UV Response To Radiation	DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Stress Base-excision Repair Double-strand Break Repair Damaged DNA Binding DNA Recombination Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Response To Stress Recombinational Repair Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage Site Of Double-strand Break Protein Localization To Site Of Double-strand Break Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Response To Radiation Mitotic DNA Integrity Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Cycle Phase Transition Chromosome Organization Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleoplasm DNA Replication Checkpoint Signaling Negative Regulation Of Cell Cycle Process Oxidized Purine DNA Binding Protein Localization To Chromosome Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Replication Checkpoint Signaling Response To Ionizing Radiation Mismatched DNA Binding Regulation Of Cell Cycle Process Response To UV Single Guanine Insertion Binding Chromosome, Telomeric Region Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Telomere Maintenance Chromatin-protein Adaptor Activity Guanine/thymine Mispair Binding Nucleotide-excision Repair Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Telomere Organization Checkpoint Clamp Complex Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?