TDG and NKX2-1

Number of citations of the paper that reports this interaction (PubMedID 11438542)
0

Data Source:
HPRD (in vitro, two hybrid)

		TDG	NKX2-1
Description		thymine DNA glycosylase	NK2 homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane PML Body	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Magnesium Ion Binding Mismatch Base Pair DNA N-glycosylase Activity Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Transcription Coregulator Activity Uracil DNA N-glycosylase Activity Protein Kinase C Binding Protein Binding ATP Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Hydrolase Activity DNA N-glycosylase Activity Protein Domain Specific Binding Mismatched DNA Binding Sodium Ion Binding Chloride Ion Binding SUMO Binding G/U Mismatch-specific Uracil-DNA Glycosylase Activity DNA-binding Transcription Factor Binding G/T Mismatch-specific Thymine-DNA Glycosylase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Chromatin Organization DNA Damage Response Epigenetic Regulation Of Gene Expression Depyrimidination Regulation Of Embryonic Development Chromosomal 5-methylcytosine DNA Demethylation, Oxidation Pathway	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phospholipid Metabolic Process Pattern Specification Process Axon Guidance Brain Development Endoderm Development Locomotory Behavior Response To Hormone Animal Organ Morphogenesis Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Telencephalon Development Globus Pallidus Development Hippocampus Development Cerebral Cortex Cell Migration Forebrain Dorsal/ventral Pattern Formation Hypothalamus Development Forebrain Neuron Fate Commitment Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Cerebral Cortex Neuron Differentiation Pituitary Gland Development Telencephalon Cell Migration Cell Differentiation Lung Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Forebrain Development Developmental Induction Leydig Cell Differentiation Positive Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Animal Organ Development Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Oligodendrocyte Differentiation Lung Saccule Development Epithelial Tube Branching Involved In Lung Morphogenesis Club Cell Differentiation Type II Pneumocyte Differentiation GABAergic Neuron Differentiation Interneuron Migration
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 SUMOylation of DNA damage response and repair proteins TET1,2,3 and TDG demethylate DNA
Drugs
Diseases			Choreoathetosis, hypothyroidism, and neonatal respiratory distress
GWAS		Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Metabolite levels ( 23823483)	Differentiated thyroid cancer ( 28703219) Height ( 18391950) Menarche (age at onset) ( 23667675 29773799) Papillary thyroid cancer ( 28703219) Thyroid cancer ( 19198613)
Interacting Genes		38 interacting genes: AR CREBBP CRK DDX39B DNMT3B DTL EP300 EPM2A ESR1 HUS1 IKZF1 JUN JUNB MX1 NKX2-1 NR3C1 PCNA PGR PML RAD1 RAD23B RAD51 RAD9A RXRA SERBP1 SETX SIRT6 SKIL SMAD4 SNIP1 STAT3 SUMO1 SUMO2 SUMO3 THRA UBE2I VDR XPC	15 interacting genes: CALR CAVIN1 CREBBP FOXA1 GATA6 HIPK2 MAPK1 NCOA1 NCOA2 NCOA3 PAX8 RARA RELA TDG WWTR1
Entrez ID		6996	7080
HPRD ID		03251	02798
Ensembl ID		ENSG00000139372	ENSG00000136352
Uniprot IDs		B4DI29 B4E127 G8JL98 Q13569	P43699
PDB IDs		1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Nucleic Acid Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Enzyme Binding Regulation Of Macromolecule Metabolic Process DNA Damage Response Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Transcription Regulator Complex Damaged DNA Binding Rhythmic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Metabolic Process DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Reproductive Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Hormone-mediated Signaling Pathway Macromolecule Metabolic Process Nuclear Steroid Receptor Activity Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Transcription Coactivator Binding Response To UV Response To Radiation	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Cellular Response To Hormone Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Multicellular Organismal Process Intracellular Receptor Signaling Pathway Positive Regulation Of Developmental Process Response To Estradiol Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Transcription Coregulator Activity Anatomical Structure Morphogenesis Chromatin Gland Development Chromatin Binding Transcription Coactivator Binding Protein-containing Complex Transcription Coactivator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Intracellular Signal Transduction Response To Hormone Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-lysine-acetyltransferase Activity DNA-templated Transcription Lung Morphogenesis Cellular Response To Thyroglobulin Triiodothyronine Regulation Of Cell Differentiation Thyroid Gland Development
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