PRMT8 and ZNF451

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PRMT8	ZNF451
Gene Name		protein arginine methyltransferase 8	zinc finger protein 451
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Nucleus
	Molecular Function	Protein Binding Histone-arginine N-methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Arginine Methylation Regulation Of Protein Binding Histone H4-R3 Methylation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		HDL cholesterol ( 19060911)
Protein-Protein Interactions		13 interactors: CEP162 COIL DCAF8 GPATCH2L HIST1H4A OFCC1 PPARA PRMT1 SERBP1 SYNCRIP TAF15 VHL ZNF451	23 interactors: AR CALCOCO2 CDC5L CPTP CREB1 FXR2 HTT JMJD6 KDM1A LZTR1 PCBD1 PIAS1 PIAS2 PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUV39H1 UBC UBE2I
Entrez ID		56341	26036
HPRD ID		11029	10332
Ensembl ID		ENSG00000111218	ENSG00000112200
Uniprot IDs		Q59GT2 Q9NR22	B4DYS2 Q96JY2 Q9Y4E5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Megakaryocyte Differentiation Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Myeloid Cell Differentiation Posttranscriptional Regulation Of Gene Expression Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H4-K20 Demethylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromatin Modification CRD-mediated MRNA Stabilization Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Chromatin Organization Behavioral Response To Nicotine Enamel Mineralization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription DNA-templated Transcription, Initiation Negative Regulation Of Glycolytic Process DNA Replication-dependent Nucleosome Assembly Regulation Of RNA Biosynthetic Process Negative Regulation Of Appetite Tooth Mineralization Regulation Of RNA Metabolic Process Positive Regulation Of Fatty Acid Beta-oxidation Peptidyl-arginine N-methylation DNA Methylation On Cytosine Histone H4-R3 Methylation Cellular Protein Modification Process Response To Hypoxia Amelogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding Chromatin Silencing At RDNA Negative Regulation Of Macrophage Derived Foam Cell Differentiation	Regulation Of Gene Expression Protein Sumoylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Histone Modification Peptidyl-amino Acid Modification Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Organelle Organization RNA Metabolic Process Cellular Protein Modification Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Chromatin Modification Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Protein Modification By Small Protein Conjugation Heterocycle Metabolic Process Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-arginine N-methylation Nucleobase-containing Compound Metabolic Process Histone H4-R3 Methylation Regulation Of Innate Immune Response Diencephalon Development Regulation Of Binding Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Histone Arginine Methylation Viral Process Peptidyl-arginine Methylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	acetylation acts attenuates beta blocks bodies causes cofactor corepressor demonstrating depletion enhances functionally h3k9 inhibits interacts localized mechanistically negatively physically promoters promyelocytic recruit regulates responses smad3 taken tgf transcriptional
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	acetylation acts attenuates beta blocks bodies causes cofactor corepressor demonstrating depletion enhances functionally h3k9 inhibits interacts localized mechanistically negatively physically promoters promyelocytic recruit regulates responses smad3 taken tgf transcriptional
Tagcloud (Intersection) ?