PRMT8 and CARM1

Number of citations of the paper that reports this interaction (PubMedID 17925405)
0

Data Source:
BioGRID (enzymatic study)

		PRMT8	CARM1
Description		protein arginine methyltransferase 8	coactivator associated arginine methyltransferase 1
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Replication Fork
	Molecular Function	Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Histone H4 Methyltransferase Activity S-adenosyl-L-methionine Binding	Transcription Cis-regulatory Region Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Methyltransferase Activity Protein Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H3R17 Methyltransferase Activity Histone Methyltransferase Activity Histone H3R2 Methyltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation Peptidyl-arginine Methylation Methylation Protein Homooligomerization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Positive Regulation Of Cell Population Proliferation Methylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase I Response To CAMP Replication Fork Reversal Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Dendrite Development
Pathways			BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 31014085) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) HDL cholesterol ( 19060911)	C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 23143594 25574825) Psoriasis vulgaris ( 26626624)
Interacting Genes		20 interacting genes: CARM1 CEP162 COIL DCAF8 FBL FYN GPATCH2L H4C1 KRTAP6-3 OFCC1 PIK3R1 PLCG1 PPARA PRMT1 PRMT2 SERBP1 TNPO2 UBL5 VHL ZNF451	34 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 KDM1A MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PRMT8 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I
Entrez ID		56341	10498
HPRD ID		11029	09158
Ensembl ID		ENSG00000111218	ENSG00000142453
Uniprot IDs		Q59GT2 Q9NR22	Q86X55
PDB IDs		4X41 5DST	2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR 6IZQ 6S70 6S71 6S74 6S77 6S79 6S7A 6S7B 6S7C 7FAI 7FAJ 7U9I 8G2H 8G2I 8SIG 8SIH
Enriched GO Terms of Interacting Partners?		Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone Methyltransferase Activity Neurotrophin TRKA Receptor Binding Methyltransferase Activity Cajal Body Nucleus Negative Regulation Of Inflammatory Response Methylation Negative Regulation Of Developmental Process Protein Methyltransferase Activity Phosphatidylinositol 3-kinase Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Macromolecule Methylation Negative Regulation Of Defense Response Protein Modification Process Nucleoplasm Chromatin Remodeling U6 SnRNA 2'-O-ribose Methyltransferase Activity Regulation Of Apoptotic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Singlet Oxygen Protein Methylation Histone H3R8 Methyltransferase Activity GATOR1 Complex Binding Negative Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transformation Of Host Cell By Virus Regulation Of Developmental Process Regulation Of Programmed Cell Death DNA-binding Transcription Factor Binding Regulation Of Inflammatory Response	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Transcription Coactivator Activity Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Cell Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Epigenetic Regulation Of Gene Expression Enzyme Binding Muscle Cell Differentiation Positive Regulation Of Cell Differentiation RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Developmental Process Nuclear Androgen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Regulation Of Cell Development
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