EPC2 and EZH2

Number of citations of the paper that reports this interaction (PMID 22659877)
26

Data Source:
BioGRID (unspecified method)

		EPC2	EZH2
Gene Name		enhancer of polycomb homolog 2 (Drosophila)	enhancer of zeste 2 polycomb repressive complex 2 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Piccolo NuA4 Histone Acetyltransferase Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex Pronucleus
	Molecular Function		Core Promoter Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Histone Methyltransferase Activity (H3-K27 Specific)
	Biological Process	DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chromatin Modification	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cerebellar Cortex Development Positive Regulation Of Ras GTPase Activity Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 21123754) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		2 interactors: EED EZH2	64 interactors: AKT1 ATP1A1 ATP1B1 ATRX BRCA1 C7orf25 CCDC85B CDK1 CDK2 CDK6 CDKN2B-AS1 CEP63 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 GADD45G GTF3C1 HDAC1 HIST1H1A HIST1H3A HIST3H3 HOTAIR JAK2 KDM1A KLHDC2 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRMT5 PSMB6 RASA1 RBBP4 RBL2 RELA RELB RPN2 RPS6KA5 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 USP7 VAV1 WDR61 WSB2 ZAK ZMYND11
Entrez ID		26122	2146
HPRD ID		13274	03342
Ensembl ID		ENSG00000135999	ENSG00000106462
Uniprot IDs		Q52LR7	Q15910 S4S3R8
PDB IDs			2C6V 4MI0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Histone Methylation Protein Methylation Regulation Of Gene Expression, Epigenetic Histone Modification Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Methylation Chromatin Modification G1 To G0 Transition Negative Regulation Of Epidermal Cell Differentiation Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation Chromatin Organization Protein Localization To Chromatin Regulation Of Histone H3-K27 Methylation Positive Regulation Of Protein Modification Process Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Striated Muscle Cell Differentiation Chromosome Organization Negative Regulation Of Transcription, DNA-templated Skeletal Muscle Tissue Regeneration Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Genetic Imprinting Negative Regulation Of Epithelial Cell Differentiation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Histone Methylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Muscle Cell Differentiation Regulation Of Epidermal Cell Differentiation Regulation Of Retinoic Acid Receptor Signaling Pathway Tissue Regeneration Regulation Of Histone Methylation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Stem Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Cellular Response To Hydrogen Peroxide DNA Methylation Cerebellar Cortex Development Regulation Of Epidermis Development Positive Regulation Of Histone Modification Regulation Of Cellular Component Organization	Chromatin Organization Chromatin Modification Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Organelle Organization Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Methylation Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Macromolecule Biosynthetic Process Methylation Cell Cycle Negative Regulation Of Histone Methylation Positive Regulation Of Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Histone Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Histone H3-K4 Methylation Intracellular Signal Transduction
Tagcloud ?		affymetrix altering barrett caudal cdx2 columnar emerges engineered epithelium gained homeobox htert immortalized intestinalization intestinalized intestine keratinocytes oesophageal oesophagus provoke remodelling rescued resemblance retroviral similarities transcriptase transiently unanswered unexpectedly	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Difference) ?		affymetrix altering barrett caudal cdx2 columnar emerges engineered epithelium gained homeobox htert immortalized intestinalization intestinalized intestine keratinocytes oesophageal oesophagus provoke remodelling rescued resemblance retroviral similarities transcriptase transiently unanswered unexpectedly	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Intersection) ?