SENP6 and PLA2G2A

Number of citations of the paper that reports this interaction (PMID 22118674)
23

Data Source:
BioGRID (enzymatic study)

		SENP6	PLA2G2A
Gene Name		SUMO1/sentrin specific peptidase 6	phospholipase A2, group IIA (platelets, synovial fluid)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Extracellular Region Extracellular Space Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Protein Binding SUMO-specific Protease Activity	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Proteolysis Protein Sumoylation Protein Desumoylation Protein Modification By Small Protein Removal Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Low-density Lipoprotein Particle Remodeling Somatic Stem Cell Maintenance Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Small Molecule Metabolic Process Phosphatidic Acid Metabolic Process Glycerophospholipid Biosynthetic Process Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium
Pathways			Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs			Indomethacin Diclofenac Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid 1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid 6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid Elaidoylamide 1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid Suramin
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		5 interactors: ARNT PLA2G2A SP1 SUMO1 SUMO2	24 interactors: ALOX12 BAG6 CEP70 CRMP1 DCN JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM
Entrez ID		26054	5320
HPRD ID		05417	01397
Ensembl ID		ENSG00000112701	ENSG00000188257
Uniprot IDs		B3KMM0 Q9GZR1	P14555
PDB IDs			1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Sequestering Of Nodal From Receptor Via Nodal Binding Embryonic Placenta Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Nodal Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Metabolic Process Placenta Development Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification PML Body Organization Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-lysine Modification Protein Localization To Nuclear Pore Determination Of Left/right Asymmetry In Lateral Mesoderm Positive Regulation Of Protein Metabolic Process Regulation Of Nodal Signaling Pathway Protein Localization To Nuclear Envelope Regulation Of Epithelial Cell Proliferation Positive Regulation Of Proteolysis Sequestering Of Extracellular Ligand From Receptor Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation By Host Of Viral Transcription Embryonic Process Involved In Female Pregnancy Positive Regulation Of Hormone Biosynthetic Process Low-density Lipoprotein Particle Remodeling Regulation Of Protein Catabolic Process MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Glycolytic Process Positive Regulation Of Protein Sumoylation Lateral Mesoderm Development Phosphatidylinositol Acyl-chain Remodeling Enucleate Erythrocyte Differentiation Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling MRNA Transcription Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Extracellular Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Embryonic Organ Development Reproductive Structure Development Regulation Of Protein Sumoylation Phosphatidylethanolamine Acyl-chain Remodeling Reproductive System Development	Protein Modification By Small Protein Removal Protein Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Proteolysis Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein K48-linked Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Dermatan Sulfate Biosynthetic Process Regulation Of Phospholipase A2 Activity Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Chondroitin Sulfate Biosynthetic Process Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Regulation Of Protein Stability Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukotriene Metabolic Process Cellular Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Cellular Protein Metabolic Process Icosanoid Biosynthetic Process Negative Regulation Of Arachidonic Acid Secretion Lipoxin B4 Biosynthetic Process Leukotriene A4 Metabolic Process Cellular Response To DNA Damage Stimulus Unsaturated Fatty Acid Biosynthetic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Negative Regulation Of Protein Metabolic Process
Tagcloud ?		attenuator catalyzing conjugated cyld dampening de defense deubiquitinase dynamically endotoxin highlights ikkgamma impairs intriguing mechanistically modifier nemo onto posttranslational potentiated reverses shape strengthening sumo sumoylation tlr tlrs toll	1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected
Tagcloud (Difference) ?		attenuator catalyzing conjugated cyld dampening de defense deubiquitinase dynamically endotoxin highlights ikkgamma impairs intriguing mechanistically nemo onto posttranslational potentiated reverses shape strengthening sumo sumoylation tlr tlrs toll	1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected
Tagcloud (Intersection) ?		modifier