SENP6

Description		SUMO specific peptidase 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SUMO-specific Endopeptidase Activity
	Biological Process	Proteolysis Protein Sumoylation Protein Desumoylation Protein Modification By Small Protein Removal Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly
Pathways
Drugs
Diseases
GWAS		Height ( 20881960 28552196) Hip circumference adjusted for BMI ( 34021172) Osteoarthritis (hip) ( 30664745)
Interacting Genes		7 interacting genes: ARNT EXO1 PLA2G2A SP1 SUMO1 SUMO2 TIAM1
Entrez ID		26054
HPRD ID		05417
Ensembl ID		ENSG00000112701
Uniprot IDs		B3KMM0 F8W6D9 Q9GZR1
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Protein Tag Activity Positive Regulation Of Protein Metabolic Process Protein Sumoylation Nuclear Body Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Double-stranded DNA 5'-3' DNA Exonuclease Activity Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Response To Wortmannin Flap Endonuclease Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Developmental Process Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Localization To Nuclear Pore Regulation Of Multicellular Organismal Process Positive Regulation Of Epithelial Cell Proliferation Response To Stress RNA Polymerase II-specific DNA-binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding Cellular Response To Stress Regulation Of Cell Population Proliferation Aryl Hydrocarbon Receptor Complex Regulation Of Endothelial Cell Proliferation Intestinal Epithelial Structure Maintenance Regulation Of Protein Metabolic Process Intestinal Stem Cell Homeostasis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To Zinc Ion Starvation Negative Regulation Of Action Potential Nuclear Stress Granule Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Small Protein Activating Enzyme Binding PML Body Organization Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity 5'-3' DNA Exonuclease Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity RNA-DNA Hybrid Ribonuclease Activity
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