SENP6 and EXO1

Number of citations of the paper that reports this interaction (PubMedID 26083678)
49

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SENP6	EXO1
Description		SUMO specific peptidase 6	exonuclease 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Plasma Membrane Nuclear Body
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SUMO-specific Endopeptidase Activity	DNA Binding Chromatin Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds 5'-flap Endonuclease Activity 5'-3' DNA Exonuclease Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' DNA Exonuclease Activity
	Biological Process	Proteolysis Protein Sumoylation Protein Desumoylation Protein Modification By Small Protein Removal Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly	Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle T-circle Formation DNA Strand Resection Involved In Replication Fork Processing
Pathways			Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS		Height ( 20881960 28552196) Hip circumference adjusted for BMI ( 34021172) Osteoarthritis (hip) ( 30664745)	Basal cell carcinoma ( 31174203) Breast cancer ( 25751625 29059683) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677)
Interacting Genes		7 interacting genes: ARNT EXO1 PLA2G2A SP1 SUMO1 SUMO2 TIAM1	20 interacting genes: ATM BLM DCAF1 H4C1 KPNA4 KPNB1 MLH1 MLH3 MSH2 MSH3 PCNA PMS2 SENP6 SFN UBE2I YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		26054	9156
HPRD ID		05417	06932
Ensembl ID		ENSG00000112701	ENSG00000174371
Uniprot IDs		B3KMM0 F8W6D9 Q9GZR1	A8K5H6 Q9UQ84
PDB IDs			3QE9 3QEA 3QEB 5UZV 5V04 5V05 5V06 5V07 5V08 5V09 5V0A 5V0B 5V0C 5V0D 5V0E 7MXQ 7MXR 7MXS 7MXT 7MXU 7MXV 7MXW 7MXX
Enriched GO Terms of Interacting Partners?		Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Protein Tag Activity Positive Regulation Of Protein Metabolic Process Protein Sumoylation Nuclear Body Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Double-stranded DNA 5'-3' DNA Exonuclease Activity Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Response To Wortmannin Flap Endonuclease Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Developmental Process Positive Regulation Of Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Localization To Nuclear Pore Regulation Of Multicellular Organismal Process Positive Regulation Of Epithelial Cell Proliferation Response To Stress RNA Polymerase II-specific DNA-binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding Cellular Response To Stress Regulation Of Cell Population Proliferation Aryl Hydrocarbon Receptor Complex Regulation Of Endothelial Cell Proliferation Intestinal Epithelial Structure Maintenance Regulation Of Protein Metabolic Process Intestinal Stem Cell Homeostasis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To Zinc Ion Starvation Negative Regulation Of Action Potential Nuclear Stress Granule Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Small Protein Activating Enzyme Binding PML Body Organization Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity 5'-3' DNA Exonuclease Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity RNA-DNA Hybrid Ribonuclease Activity	Mismatch Repair Mismatched DNA Binding Somatic Cell DNA Recombination ATP-dependent DNA Damage Sensor Activity Phosphoserine Residue Binding DNA Recombination Protein Sequestering Activity Dinucleotide Insertion Or Deletion Binding Chromosome Organization Negative Regulation Of DNA Recombination Guanine/thymine Mispair Binding Enzyme Binding Regulation Of DNA Recombination Mismatch Repair Complex Cellular Response To Stress Positive Regulation Of Isotype Switching To IgA Isotypes DNA Metabolic Process DNA Repair Somatic Recombination Of Immunoglobulin Gene Segments Nucleus DNA Damage Response Single-stranded DNA Binding Protein Domain Specific Binding Somatic Diversification Of Immunoglobulins Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Isotype Switching To IgG Isotypes Male Germ Cell Nucleus Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of DNA Metabolic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Isotype Switching To IgG Isotypes Regulation Of DNA Metabolic Process Intracellular Protein Localization Nucleoplasm Chiasma MutSbeta Complex Dinucleotide Repeat Insertion Binding Chromosome, Telomeric Region Positive Regulation Of Hippo Signaling Positive Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Synaptonemal Complex Protein Kinase C Inhibitor Activity MutLalpha Complex Single Guanine Insertion Binding Response To X-ray Reciprocal Meiotic Recombination Positive Regulation Of Isotype Switching Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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