SNX6 and LEPR

Number of citations: 0 (PubMedID 11279102)
Data Source: HPRD (in vitro, in vivo)

		SNX6	LEPR
Name		sorting nexin 6	leptin receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Endosome Early Endosome Cytosol Membrane Retromer Complex Retromer, Tubulation Complex Cytoplasmic Vesicle Early Endosome Membrane Tubular Endosome Postsynaptic Early Endosome Glutamatergic Synapse	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Lipid Binding Dynactin Binding Type I Transforming Growth Factor Beta Receptor Binding Phosphatidylinositol Binding Protein Homodimerization Activity	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity Signaling Receptor Activity Identical Protein Binding
	Biological Process	Intracellular Protein Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Regulation Of Macroautophagy Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Histamine Secretion By Mast Cell Cellular Response To Amyloid-beta	Angiogenesis Glycogen Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy Glial Cell Proliferation Cytokine-mediated Signaling Pathway Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling System Development Regulation Of Transport Regulation Of Feeding Behavior Energy Homeostasis Cell Surface Receptor Signaling Pathway Via STAT Bone Growth Positive Regulation Of Cold-induced Thermogenesis Transport Across Blood-brain Barrier
Drugs		None	Leptin Metreleptin
GWAS		Atrial fibrillation ( 29892015 ) Celiac disease ( 23936387 ) Diastolic blood pressure ( 30224653 ) Normal facial asymmetry (angle of surface orientation score) ( 30631343 )	Adult body size ( 32376654 ) Age at voice drop ( 27182965 ) Alanine aminotransferase levels ( 34315874 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Blood protein levels ( 30072576 ) BMI at 1 year old ( 31575865 ) BMI at 1.5 years old ( 31575865 ) BMI at 3 months old ( 31575865 ) BMI at 6 months old ( 31575865 ) BMI at 8 months old ( 31575865 ) BMI at adiposity peak ( 31840077 ) Body size at age 10 ( 32376654 ) C-reactive protein ( 23844046 18439548 22939635 19567438 ) C-reactive protein levels ( 33339817 21300955 29878111 30388399 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Eosinophil percentage of white cells ( 32888494 ) Fasting plasma glucose (childhood) ( 25223902 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Granulocyte count ( 27863252 ) HDL cholesterol levels ( 32203549 ) Hemoglobin ( 32888494 ) Hip circumference ( 28552196 ) Iron status biomarkers (iron levels) ( 33536631 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Menarche (age at onset) ( 25231870 ) Metabolic traits ( 19060910 ) Molybdenum levels ( 26025379 ) Monocyte percentage of white cells ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Nonalcoholic steatohepatitis ( 32298765 ) Obesity (early onset extreme) ( 23563609 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Soluble leptin receptor levels ( 20167575 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 27863252 )
Novel Interactors		1 novel interactors: RAG1	None recorded
Interacting Genes		29 interacting genes: ACVR2B ACVRL1 BMPR1B BRCA1 BRMS1 CALM1 COIL CSNK2A2 CUL3 DISC1 EGFR ESR1 INSR ITSN1 LEPR NDEL1 NRP1 OGT OPTN PDGFRA PIM1 SNX1 SNX2 SNX4 TEX11 TGFBR1 TGFBR2 TNIK TPT1	17 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 USP7 XRN1
Entrez ID		58533	3953
HPRD ID		12086	03001
Ensembl ID		ENSG00000129515	ENSG00000116678
Uniprot IDs		A0A0A0MRI2 Q9UNH7	P48357 Q4G138
PDB IDs		Not available	3V6O 6E2P 7Z3Q 8AVE 8AVF 8AVO 8X80 8X81 8X85
GO Terms Enriched among Interactors		Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signal Transduction Receptor Complex Regulation Of Signaling Regulation Of Developmental Process Protein Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Activin Binding Kinase Activity Anatomical Structure Morphogenesis Regulation Of Intracellular Signal Transduction Retina Vasculature Development In Camera-type Eye Positive Regulation Of Developmental Process Positive Regulation Of Signal Transduction Developmental Process Positive Regulation Of Cell Population Proliferation Leptin Receptor Binding Cellular Response To Growth Factor Stimulus Positive Regulation Of Multicellular Organismal Process Animal Organ Development Cell Surface Receptor Signaling Pathway Signal Transduction Transforming Growth Factor Beta Receptor Activity, Type I Response To Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Animal Organ Morphogenesis Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity Protein Serine/threonine Kinase Activity Transferase Activity Multicellular Organism Development Protein-containing Complex Regulation Of Programmed Cell Death System Development Transferrin Receptor Binding Negative Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation SMAD Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Vasculature Development Identical Protein Binding	Leptin Receptor Binding Retromer, Tubulation Complex Insulin Receptor Binding Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Peptide Hormone Receptor Binding Transferrin Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Metabolic Process Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Autophagy Retromer Complex Negative Regulation Of Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Cytosol Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Autophagy Phosphatidylinositol Binding Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Regulation Of Hormone Secretion Regulation Of Intracellular Transport Epidermal Growth Factor Receptor Binding Regulation Of Nucleocytoplasmic Transport Regulation Of Transport Regulation Of Immune System Process Regulation Of Defense Response Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hormone Secretion Establishment Of Protein Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Regulation Of Protein Localization To Nucleus