ARMC8 and TNNT1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ARMC8	TNNT1
Description		armadillo repeat containing 8	troponin T1, slow skeletal type
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol GID Complex Specific Granule Lumen Tertiary Granule Lumen	Cytosol Troponin Complex
	Molecular Function	Protein Binding	Protein Binding Tropomyosin Binding Troponin T Binding
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Skeletal Muscle Contraction Regulation Of Muscle Contraction Transition Between Fast And Slow Fiber Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Negative Regulation Of Muscle Contraction
Pathways		Neutrophil degranulation Regulation of pyruvate metabolism	Striated Muscle Contraction
Drugs
Diseases			Nemaline myopathy
GWAS		A body shape index ( 34021172) Mean spheric corpuscular volume ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Height ( 31562340)
Interacting Genes		10 interacting genes: CIB3 CTNNA1 GID8 PKP1 PKP2 STX6 TCF12 TNNT1 USP25 ZMYND12	69 interacting genes: ARMC8 BLOC1S2 BMPR1B CCDC136 CCDC85B CHD3 CLIP4 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HSP90AB1 IMMT KAT5 KRT27 KRT40 LARP1 LDOC1 MARS1 MORF4L1 MYOM2 NACAD NAGK NFE2L2 NINL NSG2 OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SBK3 SDCBP2 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TNNT2 TPM1 TPM3 TRA2A TRIM63 TSPYL2 TULP3 UBE2D1 VIM WDCP ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768
Entrez ID		25852	7138
HPRD ID		09992	01841
Ensembl ID		ENSG00000114098	ENSG00000105048
Uniprot IDs		B7Z637 Q8IUR7	P13805
PDB IDs		7NSC
Enriched GO Terms of Interacting Partners?		Intermediate Filament Binding Intermediate Filament Bundle Assembly Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Cell-cell Junction Organization Desmosome Adherens Junction Cell Junction Intercalated Disc Cell Junction Assembly Cornified Envelope Maintenance Of Protein Localization At Cell Tip Slow-twitch Skeletal Muscle Fiber Contraction Cadherin Binding Intermediate Filament Organization Desmosome Maintenance Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Anchoring Junction Negative Regulation Of Integrin-mediated Signaling Pathway Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Synaptic Vesicle To Endosome Fusion Negative Regulation Of Interleukin-17-mediated Signaling Pathway Cell Junction Organization Maintenance Of Animal Organ Identity Troponin T Binding Cell-cell Adhesion Cellular Response To Indole-3-methanol Transepithelial Water Transport Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Ubiquitin-like Protein Peptidase Activity Response To Indole-3-methanol Positive Regulation Of Cytoplasmic Translational Initiation Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Interleukin-17A-mediated Signaling Pathway Apical Junction Assembly Gap Junction Assembly Zonula Adherens Nuclear Stress Granule Intermediate Filament Ameloblast Differentiation Regulation Of Muscle Contraction Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Response To Gonadotropin-releasing Hormone Troponin Complex Transition Between Fast And Slow Fiber Negative Regulation Of ERAD Pathway	Troponin Complex Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Muscle System Process Cardiac Troponin Complex Cardiac Muscle Tissue Morphogenesis Muscle Contraction Troponin T Binding Muscle Filament Sliding I-SMAD Binding Muscle Tissue Morphogenesis Actin-myosin Filament Sliding Striated Muscle Contraction Protein Binding Skeletal Muscle Contraction Primary MiRNA Processing Homomeric SMAD Protein Complex Actin-mediated Cell Contraction Contractile Muscle Fiber Regulation Of Hematopoietic Stem Cell Differentiation Tissue Morphogenesis Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Troponin C Binding Regulation Of Muscle System Process Regulation Of Muscle Contraction Sarcomere Response To Muramyl Dipeptide Regulation Of Primary Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Troponin I Binding Muscle Thin Filament Tropomyosin Cytosol Actin Filament-based Movement Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cytoskeleton Organization Transforming Growth Factor Beta Receptor Activity, Type I Disordered Domain Specific Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process R-SMAD Binding Cytoplasm Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Stem Cell Differentiation Calcium-dependent Protein Binding SMAD Protein Complex Trophoblast Cell Migration Transition Between Fast And Slow Fiber Cardiac Myofibril
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