ARMC8 and USP25

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ARMC8	USP25
Description		armadillo repeat containing 8	ubiquitin specific peptidase 25
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol GID Complex Specific Granule Lumen Tertiary Granule Lumen	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding Deubiquitinase Activity
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Oxidative Stress Protein Modification Process Interleukin-17A-mediated Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Response To Oxidative Stress Negative Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of ERAD Pathway
Pathways		Neutrophil degranulation Regulation of pyruvate metabolism	Ub-specific processing proteases
Drugs
Diseases
GWAS		A body shape index ( 34021172) Mean spheric corpuscular volume ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		10 interacting genes: CIB3 CTNNA1 GID8 PKP1 PKP2 STX6 TCF12 TNNT1 USP25 ZMYND12	37 interacting genes: ACTA1 ARMC8 CDC73 CNTN1 EIF4A3 FBXL17 FLNC GAPDH GDI1 MAGEB4 MAVS MID2 MT2A NAP1L3 PAX6 PUS10 RAD23A RAD23B RPS10-NUDT3 RSL1D1 SENP1 SKIL SNRNP70 SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS TNKS2 TUBB UBC UBE2I VPS45 YARS1 ZNF426 ZNF841
Entrez ID		25852	29761
HPRD ID		09992	05296
Ensembl ID		ENSG00000114098	ENSG00000155313
Uniprot IDs		B7Z637 Q8IUR7	Q9UHP3
PDB IDs		7NSC	2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?		Intermediate Filament Binding Intermediate Filament Bundle Assembly Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Cell-cell Junction Organization Desmosome Adherens Junction Cell Junction Intercalated Disc Cell Junction Assembly Cornified Envelope Maintenance Of Protein Localization At Cell Tip Slow-twitch Skeletal Muscle Fiber Contraction Cadherin Binding Intermediate Filament Organization Desmosome Maintenance Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Anchoring Junction Negative Regulation Of Integrin-mediated Signaling Pathway Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Synaptic Vesicle To Endosome Fusion Negative Regulation Of Interleukin-17-mediated Signaling Pathway Cell Junction Organization Maintenance Of Animal Organ Identity Troponin T Binding Cell-cell Adhesion Cellular Response To Indole-3-methanol Transepithelial Water Transport Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Ubiquitin-like Protein Peptidase Activity Response To Indole-3-methanol Positive Regulation Of Cytoplasmic Translational Initiation Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Interleukin-17A-mediated Signaling Pathway Apical Junction Assembly Gap Junction Assembly Zonula Adherens Nuclear Stress Granule Intermediate Filament Ameloblast Differentiation Regulation Of Muscle Contraction Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Response To Gonadotropin-releasing Hormone Troponin Complex Transition Between Fast And Slow Fiber Negative Regulation Of ERAD Pathway	Presynaptic Cytosol Protein Tag Activity Protein Sumoylation Postsynaptic Cytosol Nucleus Post-translational Protein Modification Protein Modification By Small Protein Conjugation PML Body Protein Poly-ADP-ribosylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding Positive Regulation Of Telomere Capping Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Glutamatergic Synapse Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Regulation Of Telomere Capping Protein Localization To Organelle Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Cytosol Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Proteasome Binding Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-specific Protease Binding Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding Nuclear Pore NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Response To Cytokine
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