GAK and CLTC

Number of citations of the paper that reports this interaction (PMID 12732633)
13

Data Source:
HPRD (in vitro)

		GAK	CLTC
Gene Name		cyclin G associated kinase	clathrin, heavy chain (Hc)
Image
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Focal Adhesion Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Cytoplasm Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Vesicle Trans-Golgi Network Membrane Melanosome Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome Clathrin Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Poly(A) RNA Binding
	Biological Process	Protein Phosphorylation Endoplasmic Reticulum Organization Golgi Organization Cell Cycle Epidermal Cell Differentiation Intrahepatic Bile Duct Development Cell Development Forebrain Morphogenesis Establishment Of Skin Barrier Clathrin Coat Disassembly Clathrin-mediated Endocytosis Positive Regulation Of Neural Precursor Cell Proliferation	Osteoblast Differentiation Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Transferrin Transport Membrane Organization Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Axon guidance Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking WNT5A-dependent internalization of FZD4 EPH-Ephrin signaling Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Parkinson's disease ( 20711177 21292315 22438815 21738487) Parkinson's disease (familial) ( 18985386)
Protein-Protein Interactions		12 interactors: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 USO1	60 interactors: AMPH AP1B1 AP1G1 AP2A2 AP2B1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 EHD1 EP300 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL PICALM PPP1CA PPP1CC PRKACA PXN QARS SCYL2 SNX5 SNX9 SRC STAM STAMBP SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9
Entrez ID		2580	1213
HPRD ID		03631	00350
Ensembl ID		ENSG00000178950	ENSG00000141367
Uniprot IDs		E9PGR2 O14976	Q00610
PDB IDs		3LL6	2XZG 4G55
Enriched GO Terms of Interacting Partners?		Intracellular Transport Establishment Of Localization In Cell Membrane Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Golgi Vesicle Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cellular Localization Regulation Of Defense Response To Virus By Virus Cell Growth Intracellular Protein Transport Regulation Of Protein Localization To Plasma Membrane Antigen Processing And Presentation Of Peptide Antigen Viral Process Transport Regulation Of Defense Response To Virus Antigen Processing And Presentation Developmental Process Cellular Protein Localization Negative Regulation Of Biosynthetic Process Regulation Of Protein Localization Protein Transport Axon Guidance Establishment Of Protein Localization Negative Regulation Of Protein Localization To Plasma Membrane Cell Differentiation Anatomical Structure Morphogenesis Growth Regulation Of Cellular Localization Regulation Of Cellular Response To Heat Axonogenesis Cell Development Axon Development Neuron Differentiation Protein Localization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Endocytosis Regulation Of Phosphorylation Cytoplasmic Transport Organelle Organization Immune System Process Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Neuron Apoptotic Process Brain Development	Vesicle-mediated Transport Endocytosis Transport Establishment Of Localization In Cell Intracellular Transport Cellular Localization Intracellular Protein Transport Cellular Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport ERBB Signaling Pathway Protein Transport Signaling Establishment Of Protein Localization Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Endocytosis Negative Regulation Of ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Membrane Organization Positive Regulation Of Transport Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Synaptic Transmission Endosomal Transport Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Signal Transduction Regulation Of Defense Response To Virus By Virus Nervous System Development Receptor-mediated Endocytosis Regulation Of Cellular Component Organization Cell-cell Signaling Response To Stimulus Positive Regulation Of Receptor-mediated Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Receptor Internalization Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Endocytosis
Tagcloud ?		atp13a2 bst1 conclusively confirmation discuss dj1 eif4g1 familial fbxo7 gba gigyf2 growing hla hopefully htra2 loci lrrk2 mapt park16 parkin parkinson parkinsonism pink1 pla2g6 rare respective snca sporadic uchl1	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Difference) ?		atp13a2 bst1 conclusively confirmation discuss dj1 eif4g1 familial fbxo7 gba gigyf2 growing hla hopefully htra2 loci lrrk2 mapt park16 parkin parkinson parkinsonism pink1 pla2g6 rare respective snca sporadic uchl1	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Intersection) ?