GAK

Gene Name		cyclin G associated kinase
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Gene Ontology Annotations	Cellular Component	Golgi Apparatus Focal Adhesion Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Protein Phosphorylation Endoplasmic Reticulum Organization Golgi Organization Cell Cycle Epidermal Cell Differentiation Intrahepatic Bile Duct Development Cell Development Forebrain Morphogenesis Establishment Of Skin Barrier Clathrin Coat Disassembly Clathrin-mediated Endocytosis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Parkinson's disease ( 20711177 21292315 22438815 21738487) Parkinson's disease (familial) ( 18985386)
Protein-protein Interactions		12 interactors: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 USO1
Entrez ID		2580
HPRD ID		03631
Ensembl ID		ENSG00000178950
Uniprot IDs		E9PGR2 O14976
PDB IDs		3LL6
Enriched GO Terms of Interacting Partners?		Intracellular Transport Establishment Of Localization In Cell Membrane Organization Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Golgi Vesicle Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cellular Localization Regulation Of Defense Response To Virus By Virus Cell Growth Intracellular Protein Transport Regulation Of Protein Localization To Plasma Membrane Antigen Processing And Presentation Of Peptide Antigen Viral Process Transport Regulation Of Defense Response To Virus Antigen Processing And Presentation Developmental Process Cellular Protein Localization Negative Regulation Of Biosynthetic Process Regulation Of Protein Localization Protein Transport Axon Guidance Establishment Of Protein Localization Negative Regulation Of Protein Localization To Plasma Membrane Cell Differentiation Anatomical Structure Morphogenesis Growth Regulation Of Cellular Localization Regulation Of Cellular Response To Heat Axonogenesis Cell Development Axon Development Neuron Differentiation Protein Localization Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Endocytosis Regulation Of Phosphorylation Cytoplasmic Transport Organelle Organization Immune System Process Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Neuron Apoptotic Process Brain Development
Tagcloud ?		atp13a2 bst1 conclusively confirmation discuss dj1 eif4g1 familial fbxo7 gba gigyf2 growing hla hopefully htra2 loci lrrk2 mapt park16 parkin parkinson parkinsonism pink1 pla2g6 rare respective snca sporadic uchl1