RAB3GAP2 and FEZ1

Number of citations of the paper that reports this interaction (PMID 16484223)
14

Data Source:
HPRD (two hybrid)

		RAB3GAP2	FEZ1
Gene Name		RAB3 GTPase activating protein subunit 2 (non-catalytic)	fasciculation and elongation protein zeta 1 (zygin I)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Protein Complex	Cytoplasm Mitochondrion Centrosome Microtubule Plasma Membrane Microtubule Cytoskeleton Axon Dendrite
	Molecular Function	GTPase Activator Activity Enzyme Activator Activity Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding Enzyme Regulator Activity Protein Heterodimerization Activity	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Rab GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization	Transport Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Establishment Of Mitochondrion Localization Cellular Response To Growth Factor Stimulus
Pathways
Drugs
Diseases
GWAS			Schizophrenia ( 22688191 23894747)
Protein-Protein Interactions		3 interactors: EXOSC6 FEZ1 RAB3GAP1	57 interactors: BARD1 BORA BRD1 C16orf59 C8orf33 CCL7 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT KIAA1377 LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 SMEK2 STAR TAC3 TAF1D TAF9 TBC1D25 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		25782	9638
HPRD ID		11471	09212
Ensembl ID		ENSG00000118873	ENSG00000149557
Uniprot IDs		Q9H2M9	Q99689
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Glutamate Secretion DNA Deamination Positive Regulation Of Amino Acid Transport Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Glutamate Secretion Negative Regulation Of Macroautophagy Lipid Particle Organization Establishment Of Mitochondrion Localization Positive Regulation Of Neurotransmitter Secretion Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Hypothalamus Development Isotype Switching Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Negative Regulation Of Autophagy Somatic Recombination Of Immunoglobulin Gene Segments Mitochondrion Localization Face Morphogenesis Somatic Diversification Of Immunoglobulins Head Morphogenesis Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response System Development B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Face Development Regulation Of Neuronal Synaptic Plasticity Body Morphogenesis Immunoglobulin Production Multicellular Organismal Development Regulation Of Neurotransmitter Secretion Anatomical Structure Development Regulation Of Dendrite Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential DNA Modification Diencephalon Development Limbic System Development Developmental Process Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Dendrite Development	Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Organelle Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Process Vesicle Transport Along Microtubule Cell Cycle Mitotic Cell Cycle Microtubule-based Process Microtubule Cytoskeleton Organization Regulation Of Metabolic Process Response To Radiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Heterocycle Metabolic Process Cellular Process Cellular Homeostasis Organelle Transport Along Microtubule Positive Regulation Of Metabolic Process Response To Ionizing Radiation Response To Stimulus Movement Of Cell Or Subcellular Component Cell Division Regulation Of Intracellular Signal Transduction Cell Cycle Process Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Synaptic Transmission Regulation Of Microtubule-based Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Establishment Or Maintenance Of Cell Polarity Cellular Metabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Process Homeostatic Process Regulation Of Signal Transduction Regulation Of Signaling Mitochondrial Calcium Ion Homeostasis Regulation Of Organelle Organization Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Establishment Of Protein Localization To Organelle Anatomical Structure Development Nervous System Development RNA Metabolic Process Diencephalon Development Transcription, DNA-templated
Tagcloud ?		acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi gtpase heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Difference) ?		acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi gtpase heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Intersection) ?