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RAB3GAP2 and EXOSC6
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
HPRD
(two hybrid)
RAB3GAP2
EXOSC6
Gene Name
RAB3 GTPase activating protein subunit 2 (non-catalytic)
exosome component 6
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Protein Complex
Exosome (RNase Complex)
Nucleolus
Cytosol
Molecular Function
GTPase Activator Activity
Enzyme Activator Activity
Rab Guanyl-nucleotide Exchange Factor Activity
Rab GTPase Binding
Enzyme Regulator Activity
Protein Heterodimerization Activity
Exoribonuclease Activity
Poly(A) RNA Binding
Biological Process
Intracellular Protein Transport
Positive Regulation Of Rab GTPase Activity
Positive Regulation Of Catalytic Activity
Regulation Of GTPase Activity
Positive Regulation Of GTPase Activity
Establishment Of Protein Localization To Endoplasmic Reticulum Membrane
Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
DNA Deamination
Isotype Switching
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions
3 interactors:
EXOSC6
FEZ1
RAB3GAP1
35 interactors:
C1QBP
CHPF
DCP1B
DIS3
DNAJC30
EIF3I
ESRRA
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC7
EXOSC8
EXOSC9
GSE1
LSM1
LSM7
LSM8
MAN2C1
MIF4GD
MOCS3
MPP6
MRPL4
MRPS18B
NDUFA13
NUDT21
PSMB1
RAB3GAP2
SKIV2L2
SRSF3
TUFM
UPF2
XRN1
ZFP36
Entrez ID
25782
118460
HPRD ID
11471
12107
Ensembl ID
ENSG00000118873
ENSG00000223496
Uniprot IDs
Q9H2M9
Q5RKV6
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization
Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization
Establishment Of Protein Localization To Endoplasmic Reticulum Membrane
Positive Regulation Of Glutamate Secretion
DNA Deamination
Positive Regulation Of Amino Acid Transport
Regulation Of Short-term Neuronal Synaptic Plasticity
Regulation Of Glutamate Secretion
Negative Regulation Of Macroautophagy
Lipid Particle Organization
Establishment Of Mitochondrion Localization
Positive Regulation Of Neurotransmitter Secretion
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Hypothalamus Development
Isotype Switching
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Negative Regulation Of Autophagy
Somatic Recombination Of Immunoglobulin Gene Segments
Mitochondrion Localization
Face Morphogenesis
Somatic Diversification Of Immunoglobulins
Head Morphogenesis
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
System Development
B Cell Activation Involved In Immune Response
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Face Development
Regulation Of Neuronal Synaptic Plasticity
Body Morphogenesis
Immunoglobulin Production
Multicellular Organismal Development
Regulation Of Neurotransmitter Secretion
Anatomical Structure Development
Regulation Of Dendrite Morphogenesis
Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of Postsynaptic Membrane Potential
DNA Modification
Diencephalon Development
Limbic System Development
Developmental Process
Establishment Of Protein Localization To Endoplasmic Reticulum
Regulation Of Dendrite Development
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Metabolic Process
MRNA Catabolic Process
RNA Catabolic Process
RRNA Metabolic Process
Aromatic Compound Catabolic Process
Ribosome Biogenesis
RRNA Processing
Ribonucleoprotein Complex Biogenesis
Gene Expression
Cellular Macromolecule Catabolic Process
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
NcRNA Metabolic Process
Nuclear MRNA Surveillance
RNA Metabolic Process
RNA Surveillance
RRNA Catabolic Process
Maturation Of 5.8S RRNA
RNA Phosphodiester Bond Hydrolysis
Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Catabolic Process
Nucleobase-containing Compound Metabolic Process
Histone MRNA Catabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Processing
Cellular Metabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
CUT Catabolic Process
Histone MRNA Metabolic Process
MRNA Processing
RNA Splicing
Metabolic Process
RNA 3'-end Processing
RNA Splicing, Via Transesterification Reactions
RNA Localization
DNA Deamination
Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Intracellular MRNA Localization
Mitochondrial Translational Elongation
MRNA 3'-end Processing
Mitochondrion Organization
Mitochondrial Translation
MRNA Splicing, Via Spliceosome
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Tagcloud
?
acidic
adaptor
anchored
binds
catalytic
compartment
consists
envelope
ergic
etc
execute
ff
ffat
golgi
gtpase
heterodimer
motif
phenylalanines
potently
recruit
reduces
substitution
tail
traffic
vap
vesicle
Tagcloud (Difference)
?
acidic
adaptor
anchored
binds
catalytic
compartment
consists
envelope
ergic
etc
execute
ff
ffat
golgi
gtpase
heterodimer
motif
phenylalanines
potently
recruit
reduces
substitution
tail
traffic
vap
vesicle
Tagcloud (Intersection)
?