RAB3GAP2 and EXOSC6

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		RAB3GAP2	EXOSC6
Description		RAB3 GTPase activating non-catalytic protein subunit 2	exosome component 6
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GO Annotations	Cellular Component	Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex Presynaptic Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Enzyme Activator Activity Enzyme Regulator Activity Small GTPase Binding	RNA Binding RNA Exonuclease Activity
	Biological Process	Intracellular Protein Transport Macroautophagy Regulation Of GTPase Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Synaptic Signaling Positive Regulation Of Protein Lipidation Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly	DNA Metabolic Process RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases		Martsolf syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) BMI x environmental factors (excluding physical activity) interaction ( 33654129) Breast size ( 27182965)	Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)
Interacting Genes		5 interacting genes: CEBPA EXOSC6 FEZ1 RAB3GAP1 UBC	34 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		25782	118460
HPRD ID		11471	12107
Ensembl ID		ENSG00000118873	ENSG00000223496
Uniprot IDs		Q9H2M9	Q5RKV6
PDB IDs		8VYB	2NN6 6D6Q 6D6R 6H25 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagosome Assembly Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Vacuole Organization CHOP-C/EBP Complex Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Macroautophagy Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Protein Lipidation Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Glutamate Secretion, Neurotransmission Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Response To Phenylpropanoid Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Mitochondrion Organization Urea Cycle Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell Activation STAT Family Protein Binding Osteoblast Development Fat Cell Proliferation Protein Tag Activity Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Autophagosome Assembly Regulation Of Autophagy Regulation Of Organelle Assembly Rab Protein Signal Transduction Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Glutamate Secretion Hypothalamus Development Regulation Of Short-term Neuronal Synaptic Plasticity Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex)	Exosome (RNase Complex) RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance MRNA Metabolic Process Cytoplasmic Exosome (RNase Complex) Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) Nuclear RNA Surveillance RNA Surveillance RNA Exonuclease Activity RRNA Catabolic Process U4 SnRNA 3'-end Processing RNA Binding RNA Metabolic Process SnRNA Metabolic Process 3'-5'-RNA Exonuclease Activity Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Processing Macromolecule Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing RRNA 3'-end Processing TRNA Decay MRNA 3'-UTR AU-rich Region Binding RRNA Metabolic Process SnRNA Processing Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process RRNA Processing Catabolic Process Macromolecule Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Negative Regulation Of Gene Expression U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Histone MRNA Catabolic Process Sno(s)RNA Metabolic Process CUT Catabolic Process Histone MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Binding Nucleolus
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