RAB3GAP2 and RAB3GAP1

Number of citations of the paper that reports this interaction (PMID 22863883)
15

Data Source:
BioGRID (biochemical, affinity chromatography technology)
HPRD (in vivo)

		RAB3GAP2	RAB3GAP1
Gene Name		RAB3 GTPase activating protein subunit 2 (non-catalytic)	RAB3 GTPase activating protein subunit 1 (catalytic)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Protein Complex	Cytoplasm Protein Complex Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network
	Molecular Function	GTPase Activator Activity Enzyme Activator Activity Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding Enzyme Regulator Activity Protein Heterodimerization Activity	Rab GTPase Activator Activity Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Rab GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization	Brain Development Hypothalamus Development Positive Regulation Of Rab GTPase Activity Lipid Particle Organization Camera-type Eye Development Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Excitatory Postsynaptic Membrane Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization
Pathways
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) Corneal structure ( 21979947)
Protein-Protein Interactions		3 interactors: EXOSC6 FEZ1 RAB3GAP1	8 interactors: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7
Entrez ID		25782	22930
HPRD ID		11471	16002
Ensembl ID		ENSG00000118873	ENSG00000115839
Uniprot IDs		Q9H2M9	B9A6J2 C9J837 Q15042
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Glutamate Secretion DNA Deamination Positive Regulation Of Amino Acid Transport Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Glutamate Secretion Negative Regulation Of Macroautophagy Lipid Particle Organization Establishment Of Mitochondrion Localization Positive Regulation Of Neurotransmitter Secretion Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Hypothalamus Development Isotype Switching Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Negative Regulation Of Autophagy Somatic Recombination Of Immunoglobulin Gene Segments Mitochondrion Localization Face Morphogenesis Somatic Diversification Of Immunoglobulins Head Morphogenesis Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response System Development B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Face Development Regulation Of Neuronal Synaptic Plasticity Body Morphogenesis Immunoglobulin Production Multicellular Organismal Development Regulation Of Neurotransmitter Secretion Anatomical Structure Development Regulation Of Dendrite Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential DNA Modification Diencephalon Development Limbic System Development Developmental Process Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Dendrite Development	Rab Protein Signal Transduction Intracellular Protein Transport Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Transport Ras Protein Signal Transduction Establishment Of Protein Localization Intracellular Transport Protein Localization Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Vesicle Size Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Phagosome-lysosome Fusion Transport Phagosome Acidification Negative Regulation Of Macroautophagy Phagolysosome Assembly Establishment Of Mitochondrion Localization Intracellular PH Reduction Axon Guidance PH Reduction
Tagcloud ?		acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi gtpase heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle	acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi gtpase heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi gtpase heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle