RAB3GAP2

Description		RAB3 GTPase activating non-catalytic protein subunit 2
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GO Annotations	Cellular Component	Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex Presynaptic Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Enzyme Activator Activity Enzyme Regulator Activity Small GTPase Binding
	Biological Process	Intracellular Protein Transport Macroautophagy Regulation Of GTPase Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Synaptic Signaling Positive Regulation Of Protein Lipidation Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly
Pathways		COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Martsolf syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) BMI x environmental factors (excluding physical activity) interaction ( 33654129) Breast size ( 27182965)
Interacting Genes		5 interacting genes: CEBPA EXOSC6 FEZ1 RAB3GAP1 UBC
Entrez ID		25782
HPRD ID		11471
Ensembl ID		ENSG00000118873
Uniprot IDs		Q9H2M9
PDB IDs		8VYB
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagosome Assembly Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Vacuole Organization CHOP-C/EBP Complex Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Macroautophagy Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Protein Lipidation Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Glutamate Secretion, Neurotransmission Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Response To Phenylpropanoid Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Mitochondrion Organization Urea Cycle Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell Activation STAT Family Protein Binding Osteoblast Development Fat Cell Proliferation Protein Tag Activity Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Autophagosome Assembly Regulation Of Autophagy Regulation Of Organelle Assembly Rab Protein Signal Transduction Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Glutamate Secretion Hypothalamus Development Regulation Of Short-term Neuronal Synaptic Plasticity Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex)
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