KCNJ6 and ICMT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNJ6	ICMT
Description		potassium inwardly rectifying channel subfamily J member 6	isoprenylcysteine carboxyl methyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity	Protein C-terminal Carboxyl O-methyltransferase Activity Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	C-terminal Protein Methylation Protein Targeting To Membrane Nuclear Envelope Organization Methylation Protein Modification Process S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Protein Maturation
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation RAS processing
Drugs		Ethanol Halothane Ifenprodil Isavuconazole
Diseases
GWAS		Body size at age 10 ( 32376654) Clostridioides difficle infection ( 33841421) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624 28270201)
Interacting Genes		70 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMAS CMTM5 CNPY3 COL4A5 CXXC5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 GIPC1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MAP1S MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PICK1 PLLP PMP22 PNLIPRP1 PTPRD RPRM RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZBTB38 ZDHHC24	12 interacting genes: AQP6 ARL13B HRAS JAGN1 KCNJ6 MUC1 PDZK1IP1 RAC1 RAC2 RHOA RNF19B TRIM32
Entrez ID		3763	23463
HPRD ID		02929	09321
Ensembl ID		ENSG00000157542	ENSG00000116237
Uniprot IDs		P48051	B3KS61 O60725 Q7Z750
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Presynaptic Membrane Trans-synaptic Signaling Synaptic Signaling Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum Chemical Synaptic Transmission Negative Regulation Of Dopamine Secretion G-protein Activated Inward Rectifier Potassium Channel Activity Compact Myelin Inward Rectifier Potassium Channel Complex Regulation Of Sodium Ion Transport Protein Targeting Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Ion Transport Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Golgi Trans Cisterna Negative Regulation Of Synaptic Transmission	Telencephalon Cell Migration Forebrain Cell Migration GTPase Activity GTP Binding Erythrocyte Enucleation Positive Regulation Of Cellular Component Biogenesis G Protein Activity Regulation Of Cell Projection Assembly Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Positive Regulation Of Locomotion Positive Regulation Of Ruffle Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Chemotaxis Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Locomotion Regulation Of Respiratory Burst Actin Cytoskeleton Organization Cell Projection Assembly Respiratory Burst Regulation Of Actin Filament-based Process Regulation Of Reactive Oxygen Species Metabolic Process Superoxide Anion Generation Response To External Biotic Stimulus Positive Regulation Of Neutrophil Chemotaxis Myosin Binding Actin Filament-based Process Positive Regulation Of Leukocyte Migration Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Lamellipodium Assembly Establishment Or Maintenance Of Cell Polarity Cerebral Cortex Cell Migration Regulation Of Ruffle Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Wnt Signaling Pathway, Planar Cell Polarity Pathway Tissue Homeostasis Anatomical Structure Homeostasis Positive Regulation Of Lamellipodium Organization Cell Morphogenesis Lamellipodium Regulation Of Neuron Differentiation Membrane
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