KCNJ6 and BIRC5

Number of citations: 0 (PubMedID 15218035)
Data Source: BioGRID (pull down)

		KCNJ6	BIRC5
Name		potassium inwardly rectifying channel subfamily J member 6	baculoviral IAP repeat containing 5
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centriole Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Midbody Interphase Microtubule Organizing Center Chromosome Passenger Complex Protein-containing Complex Spindle Midzone Survivin Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Enzyme Binding Peptidase Inhibitor Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Heterodimerization Activity Cobalt Ion Binding Protein-folding Chaperone Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Cytokinesis Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Protein-containing Complex Localization Positive Regulation Of Exit From Mitosis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Chromosome Localization Mitotic Spindle Midzone Assembly Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation
Drugs		Ethanol Halothane Ifenprodil Isavuconazole	Reserpine Berberine LY2181308
GWAS		Body size at age 10 ( 32376654 ) Clostridioides difficle infection ( 33841421 ) Electroencephalographic traits in alcoholism ( 22554406 ) Response to placebo treatment in childhood asthma (FVC change) ( 31557306 ) Rosacea symptom severity ( 29771307 )	Blood trace element (Se levels) ( 23720494 ) Periodontitis (Mean PAL) ( 24024966 )
Novel Interactors		1 novel interactors: RPS6KA2	8 novel interactors: AANAT AKAP6 CSNK1D FASN GCGR NNMT SSH2 TLE3
Interacting Genes		70 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMAS CMTM5 CNPY3 COL4A5 CXXC5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 GIPC1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MAP1S MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PICK1 PLLP PMP22 PNLIPRP1 PTPRD RPRM RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZBTB38 ZDHHC24	27 interacting genes: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CCDC85B CDCA8 CDK1 CDK4 DIABLO EVI5 GAS2L3 H3-4 H3C14 HSP90AA1 INCENP KCNJ6 OGT RAN RASA1 STAMBPL1 XIAP XPO1
Entrez ID		3763	332
HPRD ID		02929	04520
Ensembl ID		ENSG00000157542	ENSG00000089685
Uniprot IDs		P48051	A0A0B4J1S3 H3BLT4 O15392
PDB IDs		Not available	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO 6YIE 6YIF 6YIH 7LBK 7LBO 7LBP 7LBQ 8RUP
GO Terms Enriched among Interactors		Membrane Presynaptic Membrane Trans-synaptic Signaling Synaptic Signaling Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum Chemical Synaptic Transmission Negative Regulation Of Dopamine Secretion G-protein Activated Inward Rectifier Potassium Channel Activity Compact Myelin Inward Rectifier Potassium Channel Complex Regulation Of Sodium Ion Transport Protein Targeting Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Ion Transport Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Golgi Trans Cisterna Negative Regulation Of Synaptic Transmission	Chromosome Passenger Complex Cell Division Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Mitotic Spindle Midzone Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Midzone Assembly Regulation Of Metaphase Plate Congression Spindle Microtubule Spindle Regulation Of Cytokinesis Spindle Organization Mitotic Spindle Organization Regulation Of Cell Cycle Apoptotic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Programmed Cell Death Cell Death Microtubule Cytoskeleton Organization Spindle Midzone Positive Regulation Of Chromosome Segregation Cytoplasm Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Programmed Cell Death Positive Regulation Of Cell Cycle Process Cytosol Fibroblast Apoptotic Process Spindle Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Division Protein Modification Process Chromocenter Positive Regulation Of Cytokinesis Protein-containing Complex Regulation Of Apoptotic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Neuron Apoptotic Process Transferase Activity Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cell Cycle Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint Cellular Response To Oxygen-containing Compound Mitotic Cell Cycle Mitotic Cytokinesis Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint