KCNJ6 and BCL2L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNJ6	BCL2L2
Description		potassium inwardly rectifying channel subfamily J member 6	BCL2 like 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity	Protein Binding Channel Activity Identical Protein Binding Disordered Domain Specific Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Release Of Cytochrome C From Mitochondria Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Sertoli Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Ethanol Halothane Ifenprodil Isavuconazole	Navitoclax
Diseases
GWAS		Body size at age 10 ( 32376654) Clostridioides difficle infection ( 33841421) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)	Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		70 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMAS CMTM5 CNPY3 COL4A5 CXXC5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 GIPC1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MAP1S MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PICK1 PLLP PMP22 PNLIPRP1 PTPRD RPRM RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZBTB38 ZDHHC24	53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CEBPA CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35E3 SLC35H1 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53
Entrez ID		3763	599
HPRD ID		02929	03569
Ensembl ID		ENSG00000157542	ENSG00000129473
Uniprot IDs		P48051	Q92843
PDB IDs			1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?		Membrane Presynaptic Membrane Trans-synaptic Signaling Synaptic Signaling Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum Chemical Synaptic Transmission Negative Regulation Of Dopamine Secretion G-protein Activated Inward Rectifier Potassium Channel Activity Compact Myelin Inward Rectifier Potassium Channel Complex Regulation Of Sodium Ion Transport Protein Targeting Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Ion Transport Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Golgi Trans Cisterna Negative Regulation Of Synaptic Transmission	Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Apoptotic Mitochondrial Changes Apoptotic Process Positive Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Cell Death Positive Regulation Of Programmed Cell Death Programmed Cell Death Mitochondrial Outer Membrane Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Apoptotic Signaling Pathway Regulation Of Membrane Permeability Mitochondrion Organization Cellular Response To Stress Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein-containing Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Fibroblast Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Organelle Organization Positive Regulation Of Fibroblast Apoptotic Process Cellular Response To Hypoxia Lymphocyte Apoptotic Process Thymocyte Apoptotic Process Cellular Response To Decreased Oxygen Levels Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Triglyceride Metabolic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxygen Levels Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Identical Protein Binding Leukocyte Apoptotic Process Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrion Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
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