LCE5A and LCE1F

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE5A	LCE1F
Description		late cornified envelope 5A	late cornified envelope 1F
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Epidermis Development Keratinization	Epidermis Development Keratinization
Pathways		Formation of the cornified envelope	Formation of the cornified envelope
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma and eczema ( 34155719) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic march ( 26542096) Hair morphology ( 19896111) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory skin disease ( 25574825)	Asthma ( 31619474)
Interacting Genes		88 interacting genes: ADAM12 ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CREB5 CYP21A2 CYSRT1 FBLN1 GRN HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-1 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-8 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A MACO1 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 NUTF2 PLA2G10 PLAC8 PLSCR2 PLSCR3 PLSCR4 POU4F2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRED2 SPRY1 TGFB1 TRIM42 UBE2I VASN VWC2 VWC2L ZNF655	90 interacting genes: ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CRCT1 CREB5 CYP21A2 CYSRT1 FBLN1 HOXA1 IL34 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A LCE5A MACO1 MDFI NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 OIT3 OTX1 PCSK5 PLA2G10 POU4F2 PSMB1 RAD54L2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRY1 SPRY2 SPRY3 TGFB1 TRIM42 UBE2I VASN VWC2 WFDC3
Entrez ID		254910	353137
HPRD ID		17265	13970
Ensembl ID		ENSG00000186207	ENSG00000240386
Uniprot IDs		Q5TCM9	Q5T754
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding Protein Binding Phospholipid Scramblase Activity Negative Regulation Of Lens Fiber Cell Differentiation Plasma Membrane Phospholipid Scrambling Cytosol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Protein Binding Identical Protein Binding Branch Elongation Of An Epithelium Axis Elongation Cytosol Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Ras Protein Signal Transduction Microtubule End Negative Regulation Of Cellular Response To Growth Factor Stimulus Bud Elongation Involved In Lung Branching Interstitial Matrix
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