LCE5A and KRTAP5-8

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		LCE5A	KRTAP5-8
Description		late cornified envelope 5A	keratin associated protein 5-8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytosol Intermediate Filament
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Epidermis Development Keratinization
Pathways		Formation of the cornified envelope	Keratinization
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma and eczema ( 34155719) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic march ( 26542096) Hair morphology ( 19896111) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory skin disease ( 25574825)
Interacting Genes		88 interacting genes: ADAM12 ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CREB5 CYP21A2 CYSRT1 FBLN1 GRN HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-1 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-8 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A MACO1 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 NUTF2 PLA2G10 PLAC8 PLSCR2 PLSCR3 PLSCR4 POU4F2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRED2 SPRY1 TGFB1 TRIM42 UBE2I VASN VWC2 VWC2L ZNF655	6 interacting genes: CRCT1 HHEX LCE1E LCE3A LCE5A WNT11
Entrez ID		254910	57830
HPRD ID		17265	17252
Ensembl ID		ENSG00000186207	ENSG00000241233
Uniprot IDs		Q5TCM9	O75690
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding Protein Binding Phospholipid Scramblase Activity Negative Regulation Of Lens Fiber Cell Differentiation Plasma Membrane Phospholipid Scrambling Cytosol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Keratinization Epidermis Development Tissue Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of MRNA Export From Nucleus Negative Regulation Of Cytoplasmic Translational Initiation Eukaryotic Initiation Factor 4E Binding Regionalization Secondary Palate Development Notochord Morphogenesis Nephron Tubule Morphogenesis Convergent Extension Involved In Axis Elongation Lung-associated Mesenchyme Development Negative Regulation Of Fibroblast Growth Factor Production Maintenance Of Epithelial Cell Apical/basal Polarity Primary Heart Field Specification Ureteric Bud Morphogenesis Wnt Signaling Pathway, Calcium Modulating Pathway Convergent Extension Cloacal Septation Positive Regulation Of Transforming Growth Factor Beta2 Production Atrial Septum Development Nephric Duct Development Regulation Of Transforming Growth Factor Beta2 Production Heart Field Specification Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Paraxial Mesoderm Formation Secondary Heart Field Specification Maintenance Of Cell Polarity Regulation Of Wnt Signaling Pathway DNA Binding, Bending Somite Development Regulation Of RNA Export From Nucleus Translation Regulator Activity DNA Conformation Change Specification Of Animal Organ Identity Renal Tubule Morphogenesis Neuroendocrine Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta Production Pattern Specification Process Positive Regulation Of Epithelial Cell Apoptotic Process Adrenal Gland Development TBP-class Protein Binding Mesenchymal Cell Proliferation
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