LCE5A and KRTAP10-6

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		LCE5A	KRTAP10-6
Description		late cornified envelope 5A	keratin associated protein 10-6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Epidermis Development Keratinization
Pathways		Formation of the cornified envelope	Keratinization
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma and eczema ( 34155719) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic march ( 26542096) Hair morphology ( 19896111) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory skin disease ( 25574825)
Interacting Genes		88 interacting genes: ADAM12 ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CREB5 CYP21A2 CYSRT1 FBLN1 GRN HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-1 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-8 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A MACO1 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 NUTF2 PLA2G10 PLAC8 PLSCR2 PLSCR3 PLSCR4 POU4F2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRED2 SPRY1 TGFB1 TRIM42 UBE2I VASN VWC2 VWC2L ZNF655	87 interacting genes: ADAMTSL3 AVPI1 CLK1 CLK4 DHX57 DKK2 FOXD4 HAND1 HHEX HOXB5 KIAA0040 KIF9 KRTAP10-1 KRTAP10-5 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A MOBP MT1B NAA10 NAXD NKD1 NMU NOL12 NPDC1 PBXIP1 PIN1 RSPO2 SLC33A2 SNIP1 SPATA3 STRA6 VASN WT1 YTHDC1 ZBTB24 ZC3HAV1 ZIM2 ZNF114 ZNF138 ZNF155 ZNF169 ZNF221 ZNF239 ZNF264 ZNF280C ZNF302 ZNF319 ZNF418 ZNF440 ZNF479 ZNF490 ZNF543 ZNF563 ZNF595 ZNF600 ZNF669 ZNF672 ZNF679 ZNF696 ZNF774 ZNF776 ZNF792 ZNHIT1
Entrez ID		254910	386674
HPRD ID		17265	11192
Ensembl ID		ENSG00000186207	ENSG00000188155
Uniprot IDs		Q5TCM9	P60371
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding Protein Binding Phospholipid Scramblase Activity Negative Regulation Of Lens Fiber Cell Differentiation Plasma Membrane Phospholipid Scrambling Cytosol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Keratinization Epidermis Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Tissue Development Zinc Ion Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Keratin Filament Hair Cycle Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Wnt Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Metal Ion Binding Diaphragm Development Cartilage Morphogenesis Regulation Of Macromolecule Metabolic Process
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