LCE1F and CATSPER1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE1F	CATSPER1
Description		late cornified envelope 1F	cation channel sperm associated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Plasma Membrane Cilium Membrane Motile Cilium Monoatomic Ion Channel Complex Sperm Flagellum CatSper Complex Cell Projection Sperm Principal Piece
	Molecular Function	Protein Binding Identical Protein Binding	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding
	Biological Process	Epidermis Development Keratinization	Monoatomic Ion Transport Calcium Ion Transport Spermatogenesis Cell Differentiation Flagellated Sperm Motility Monoatomic Ion Transmembrane Transport Transmembrane Transport Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Calcium Ion Transmembrane Transport
Pathways		Formation of the cornified envelope	Sperm Motility And Taxes
Drugs			Bisphenol A diglycidyl ether
Diseases
GWAS		Asthma ( 31619474)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340)
Interacting Genes		90 interacting genes: ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CRCT1 CREB5 CYP21A2 CYSRT1 FBLN1 HOXA1 IL34 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A LCE5A MACO1 MDFI NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 OIT3 OTX1 PCSK5 PLA2G10 POU4F2 PSMB1 RAD54L2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRY1 SPRY2 SPRY3 TGFB1 TRIM42 UBE2I VASN VWC2 WFDC3	119 interacting genes: ABLIM3 ADAMTSL4 AGR2 AGR3 AJUBA AKAP8L APOA2 ARID5A BEGAIN C11orf16 CARD10 CDPF1 CFAP68 CHIC2 CHRD CPSF7 CTBP2 CYSRT1 EFEMP2 EMD EYA2 FHL5 FRS3 FST GLI1 HNRNPH1 HOXA1 IKZF3 KHDRBS2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1D LCE1E LCE1F LCE2C LCE5A LIMS1 LZTS2 MDFI MTUS2 MYCL NBPF19 NOTCH2NLA PAK5 PDLIM7 PLA2G10 PLAGL2 PLSCR1 PLSCR3 PMF1-BGLAP PTPN21 RFX6 RGS19 RGS20 RIMBP3 RSPO2 SAXO4 SCRG1 SIVA1 SORBS3 SPMIP6 SPRY2 SPRY3 SSC4D TGFB1 TNS2 TRAF2 TRIM27 TRIM42 TRIM8 TRIP6 TSPAN4 VWC2 ZBTB42 ZIM2 ZNF688 ZNF774 ZNF837
Entrez ID		353137	117144
HPRD ID		13970	09396
Ensembl ID		ENSG00000240386	ENSG00000175294
Uniprot IDs		Q5T754	Q8NEC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Protein Binding Identical Protein Binding Branch Elongation Of An Epithelium Axis Elongation Cytosol Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Ras Protein Signal Transduction Microtubule End Negative Regulation Of Cellular Response To Growth Factor Stimulus Bud Elongation Involved In Lung Branching Interstitial Matrix	Intermediate Filament Keratin Filament Keratinization Epidermis Development Identical Protein Binding Hair Cycle Protein Binding Cytosol Lead Ion Binding Lung Growth Mercury Ion Binding
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