LCE1F and WFDC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE1F	WFDC3
Description		late cornified envelope 1F	WAP four-disulfide core domain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Identical Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Epidermis Development Keratinization	Antibacterial Humoral Response Innate Immune Response
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Asthma ( 31619474)
Interacting Genes		90 interacting genes: ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CRCT1 CREB5 CYP21A2 CYSRT1 FBLN1 HOXA1 IL34 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A LCE5A MACO1 MDFI NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 OIT3 OTX1 PCSK5 PLA2G10 POU4F2 PSMB1 RAD54L2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRY1 SPRY2 SPRY3 TGFB1 TRIM42 UBE2I VASN VWC2 WFDC3	2 interacting genes: GET3 LCE1F
Entrez ID		353137	140686
HPRD ID		13970	15676
Ensembl ID		ENSG00000240386	ENSG00000124116
Uniprot IDs		Q5T754	Q8IUB2
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Protein Binding Identical Protein Binding Branch Elongation Of An Epithelium Axis Elongation Cytosol Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Ras Protein Signal Transduction Microtubule End Negative Regulation Of Cellular Response To Growth Factor Stimulus Bud Elongation Involved In Lung Branching Interstitial Matrix	GET Complex Membrane Insertase Activity Protein Insertion Into ER Membrane Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Tail-anchored Membrane Protein Insertion Into ER Membrane Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Protein Insertion Into Membrane Keratinization Antigen Processing And Presentation
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