LCE1F and IL34

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE1F	IL34
Description		late cornified envelope 1F	interleukin 34
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Identical Protein Binding	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding
	Biological Process	Epidermis Development Keratinization	Positive Regulation Of Protein Phosphorylation Immune System Process Inflammatory Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cell Development Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Interleukin-34-mediated Signaling Pathway Microglial Cell Proliferation Positive Regulation Of Macrophage Proliferation Regulation Of Multicellular Organismal Development
Pathways		Formation of the cornified envelope	Other interleukin signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Asthma ( 31619474)	Alzheimer's disease ( 34099642) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cerebrospinal P-tau181p levels ( 28247064) Diffuse cutaneous systemic sclerosis ( 29293537) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Intraocular pressure ( 29785010 30054594) Malaria ( 31844061)
Interacting Genes		90 interacting genes: ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CRCT1 CREB5 CYP21A2 CYSRT1 FBLN1 HOXA1 IL34 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A LCE5A MACO1 MDFI NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 OIT3 OTX1 PCSK5 PLA2G10 POU4F2 PSMB1 RAD54L2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRY1 SPRY2 SPRY3 TGFB1 TRIM42 UBE2I VASN VWC2 WFDC3	3 interacting genes: ATXN1 LCE1F PTPRZ1
Entrez ID		353137	146433
HPRD ID		13970	14582
Ensembl ID		ENSG00000240386	ENSG00000157368
Uniprot IDs		Q5T754	J3QQT3 Q6ZMJ4
PDB IDs			4DKC 4DKD 4DKE 4DKF
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Protein Binding Identical Protein Binding Branch Elongation Of An Epithelium Axis Elongation Cytosol Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Ras Protein Signal Transduction Microtubule End Negative Regulation Of Cellular Response To Growth Factor Stimulus Bud Elongation Involved In Lung Branching Interstitial Matrix	Positive Regulation Of Gliogenesis Regulation Of Gliogenesis Learning Or Memory Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development POZ Domain Binding Regulation Of Oligodendrocyte Progenitor Proliferation Cognition Positive Regulation Of Cell Development Regulation Of Neurogenesis Regulation Of Nervous System Development Perineuronal Net Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nuclear Inclusion Body Transmembrane Receptor Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Oligodendrocyte Differentiation Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Development Regulation Of Myelination Nervous System Process Positive Regulation Of Cell Differentiation Regulation Of Glial Cell Proliferation Insulin-like Growth Factor Receptor Signaling Pathway Lung Alveolus Development
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