LCE5A and CATSPER1

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		LCE5A	CATSPER1
Description		late cornified envelope 5A	cation channel sperm associated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Plasma Membrane Cilium Membrane Motile Cilium Monoatomic Ion Channel Complex Sperm Flagellum CatSper Complex Cell Projection Sperm Principal Piece
	Molecular Function	Protein Binding Identical Protein Binding	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding
	Biological Process	Epidermis Development Keratinization	Monoatomic Ion Transport Calcium Ion Transport Spermatogenesis Cell Differentiation Flagellated Sperm Motility Monoatomic Ion Transmembrane Transport Transmembrane Transport Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Calcium Ion Transmembrane Transport
Pathways		Formation of the cornified envelope	Sperm Motility And Taxes
Drugs			Bisphenol A diglycidyl ether
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma and eczema ( 34155719) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic march ( 26542096) Hair morphology ( 19896111) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory skin disease ( 25574825)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340)
Interacting Genes		88 interacting genes: ADAM12 ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CREB5 CYP21A2 CYSRT1 FBLN1 GRN HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-1 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-8 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A MACO1 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 NUTF2 PLA2G10 PLAC8 PLSCR2 PLSCR3 PLSCR4 POU4F2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRED2 SPRY1 TGFB1 TRIM42 UBE2I VASN VWC2 VWC2L ZNF655	119 interacting genes: ABLIM3 ADAMTSL4 AGR2 AGR3 AJUBA AKAP8L APOA2 ARID5A BEGAIN C11orf16 CARD10 CDPF1 CFAP68 CHIC2 CHRD CPSF7 CTBP2 CYSRT1 EFEMP2 EMD EYA2 FHL5 FRS3 FST GLI1 HNRNPH1 HOXA1 IKZF3 KHDRBS2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1D LCE1E LCE1F LCE2C LCE5A LIMS1 LZTS2 MDFI MTUS2 MYCL NBPF19 NOTCH2NLA PAK5 PDLIM7 PLA2G10 PLAGL2 PLSCR1 PLSCR3 PMF1-BGLAP PTPN21 RFX6 RGS19 RGS20 RIMBP3 RSPO2 SAXO4 SCRG1 SIVA1 SORBS3 SPMIP6 SPRY2 SPRY3 SSC4D TGFB1 TNS2 TRAF2 TRIM27 TRIM42 TRIM8 TRIP6 TSPAN4 VWC2 ZBTB42 ZIM2 ZNF688 ZNF774 ZNF837
Entrez ID		254910	117144
HPRD ID		17265	09396
Ensembl ID		ENSG00000186207	ENSG00000175294
Uniprot IDs		Q5TCM9	Q8NEC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding Protein Binding Phospholipid Scramblase Activity Negative Regulation Of Lens Fiber Cell Differentiation Plasma Membrane Phospholipid Scrambling Cytosol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Intermediate Filament Keratin Filament Keratinization Epidermis Development Identical Protein Binding Hair Cycle Protein Binding Cytosol Lead Ion Binding Lung Growth Mercury Ion Binding
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