TEKT4 and ATG5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TEKT4	ATG5
Description		tektin 4	autophagy related 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Cytoplasm Autophagosome Cytosol Axoneme Membrane Axon Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Synapse Phagophore Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Transferase Complex
	Molecular Function	Protein Binding	Protein Binding Atg8-family Ligase Activity
	Biological Process	Cell Projection Organization Flagellated Sperm Motility Cilium Assembly Cilium Movement Involved In Cell Motility	Autophagosome Assembly Mitophagy Blood Vessel Remodeling Immune System Process Regulation Of Cytokine Production Involved In Immune Response Chromatin Organization Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Fungus Response To Iron(II) Ion Positive Regulation Of Autophagy Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Protein Ubiquitination Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Post-translational Protein Modification Negative Thymic T Cell Selection Innate Immune Response Negative Regulation Of Innate Immune Response Otolith Development Negative Regulation Of Defense Response To Virus Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Establishment Of Localization In Cell Ventricular Cardiac Muscle Cell Development Heart Contraction Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Mucus Secretion Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Axonal Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Autophagosome Maturation Regulation Of Cilium Assembly Response To Fluoride Negative Regulation Of Autophagic Cell Death Positive Regulation Of Viral Translation Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Parkinson's disease ( 34064523)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 33875642 27363682) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 19838193 27399966 26502338 23273568) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 24387989) Visceral fat ( 30942860) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		105 interacting genes: ACBD4 AIRIM AKAP8L ALAS1 AMMECR1 ANKRD55 ARID5A ATG5 BCL6 BLZF1 BORCS8-MEF2B CFAP68 CTDSP1 DDIT4L EFHC2 EYA2 FAM220A GATA1 GPSM1 GRB10 GSE1 HCK HDAC6 HNRNPH1 HNRNPM HOXA1 HOXB5 HOXC8 IKZF3 INCA1 KPRP KRT15 KRT18 KRT34 KRT35 KRT75 KRT86 KRTAP11-1 KRTAP13-1 KRTAP13-3 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP26-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LASP1 LMCD1 LNX1 MAGEA4 MIIP MORN3 MYOZ3 NANOS3 NFKBID NR5A1 PCSK5 PHF11 PKP2 PLAGL2 POLDIP3 PPP1R13B PRDM14 PRDM6 PROP1 PSMA1 PTH1R RAMAC RARA RBM48 RECK RFX6 RUSC1 SAXO4 SCN5A SLC25A6 SMAD3 SOCS4 SPATA8 SPATC1L SPG21 SPMIP6 SUV39H1 TADA2A TEKT1 TFAP4 TOX2 TRIB3 TRIP6 TSPAN4 UBASH3A USP2 VGLL1 ZFP90 ZIM2 ZMYND12 ZNF20 ZNF417 ZNF426 ZNF474 ZNF552 ZNF581 ZNF655 ZNF688	31 interacting genes: ATG10 ATG12 ATG16L1 ATG16L2 ATP23 CALCOCO2 CAPN1 CAPN2 CCHCR1 FADD FMR1 GRIPAP1 HOOK2 INCA1 IRGM KEAP1 KIAA1328 MAD1L1 MEOX2 MYC NLRP6 OPTN PSMB11 RACK1 TECPR1 TEKT4 TIAM1 TRIM21 USP13 VCP WDFY3
Entrez ID		150483	9474
HPRD ID		14518	16051
Ensembl ID		ENSG00000163060	ENSG00000057663
Uniprot IDs		A0A384MEB7 Q8WW24	A0A2R8Y718 A9UGY9 Q7Z3H3 Q9H1Y0
PDB IDs		7UNG	4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW 7W36
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Keratin Filament Nucleus Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Axonemal A Tubule Inner Sheath Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intermediate Filament Organization Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding DNA-binding Transcription Factor Activity Chromatin DNA Binding Structural Molecule Activity Histone Deacetylase Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Flagellated Sperm Motility Sperm Motility DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cilium-dependent Cell Motility Sperm Flagellum Regulation Of Primary Metabolic Process Cilium Movement Involved In Cell Motility Nucleoplasm Sequence-specific Double-stranded DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Sequence-specific DNA Binding Cilium Movement Negative Regulation Of RNA Metabolic Process Keratinization Erythrocyte Development	Autophagy Macroautophagy Regulation Of Autophagy Autophagosome Atg12-Atg5-Atg16 Complex Catabolic Process Autophagosome Membrane Regulation Of Autophagosome Maturation Autophagosome Assembly Cytosol Vacuole Organization Positive Regulation Of Catabolic Process Autophagosome Organization Cytoplasm Protein-containing Complex Disassembly Identical Protein Binding Regulation Of Macroautophagy Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Autophagosome Maturation C-terminal Protein Lipidation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Viral Genome Replication Phagophore Assembly Site Membrane Macromolecule Catabolic Process Negative Stranded Viral RNA Replication Signaling Adaptor Activity Protein Transport Positive Regulation Of Autophagy Calpain Complex BAT3 Complex Binding Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Protein-containing Complex Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of Immune System Process BH3 Domain Binding Regulation Of Proteolysis Establishment Of Protein Localization Response To Virus Stress Granule Disassembly Xenophagy Positive Regulation Of Autophagosome Maturation Viral RNA Genome Replication Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Xenophagy Post-translational Protein Modification Protein Catabolic Process Positive Regulation Of Cellular Component Organization Protein-containing Complex Organization
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