AIPL1 and TINF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		AIPL1	TINF2
Description		AIP like 1 HSP90 co-chaperone	TERF1 interacting nuclear factor 2
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GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex
	Molecular Function	Farnesylated Protein Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Unfolded Protein Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Retina Homeostasis Apoptotic Process Visual Perception Phototransduction, Visible Light Protein Farnesylation Regulation Of Opsin-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases		Leber congenital amaurosis (LCR)	Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		C-reactive protein levels ( 29403010 33339817) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hormone measurements ( 23696881) Manganese levels ( 26025379) Paclitaxel-induced cytotoxicity ( 26015512) Reading disability ( 32108986)	Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		10 interacting genes: ACD HSP90AA1 HSPA8 LBX1 NUB1 PLSCR3 POT1 SMAP1 TINF2 TXNL4B	91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		23746	26277
HPRD ID		05092	16056
Ensembl ID		ENSG00000129221	ENSG00000092330
Uniprot IDs		F1T0B5 F1T0B6 F1T0C0 F1T0C4 Q7Z3H1 Q9NZN9	B4DFJ1 Q9BSI4
PDB IDs		5U9A 5U9I 5U9J 5U9K 5V35 6PX0	3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?		Telomere Assembly Shelterin Complex Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Capping Positive Regulation Of Telomere Maintenance Regulation Of DNA Biosynthetic Process Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Regulation Of Telomere Maintenance Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Chaperone-mediated Autophagy Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Organelle Chromosome Organization Negative Regulation Of DNA Metabolic Process DNA Polymerase Binding Positive Regulation Of Telomere Maintenance Via Telomerase MHC Class II Protein Complex Binding Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Protein Refolding Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Positive Regulation Of Organelle Organization Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Regulation Of Organelle Organization Positive Regulation Of DNA Biosynthetic Process Protein Localization To Organelle Nucleic Acid Metabolic Process Negative Regulation Of Cellular Component Organization Chaperone-mediated Autophagy Translocation Complex Disassembly Protein Folding Chaperone DNA Metabolic Process	Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate
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