PLEKHA1 and CLDN14

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		PLEKHA1	CLDN14
Description		pleckstrin homology domain containing A1	claudin 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Extracellular Exosome	Endoplasmic Reticulum Plasma Membrane Bicellular Tight Junction Membrane Anchoring Junction
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Luteinization Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Ruffle Organization Leydig Cell Differentiation Multicellular Organism Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Protein Localization Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis B Cell Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Roof Of Mouth Development Face Morphogenesis Cellular Response To Hydrogen Peroxide	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Protein-containing Complex Assembly Bicellular Tight Junction Assembly
Pathways		Synthesis of PIPs at the plasma membrane	Tight junction interactions
Drugs		Citric acid
Diseases			Deafness, autosomal recessive
GWAS		Age-related macular degeneration ( 23536807 23577725) Age-related macular degeneration (extreme sampling) ( 23577725) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Birth weight ( 27680694 31043758) Central corneal thickness ( 32528159) Femoral neck bone mineral density ( 29499414) Height ( 20189936 31562340) Hip circumference adjusted for BMI ( 34021172) Medication use (thyroid preparations) ( 31015401) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 30718926 30297969 30054458 32499647 28869590 28566273 24509480)	Blood urea nitrogen levels ( 31152163) Bone mineral density ( 24249740) Estimated glomerular filtration rate ( 31015462 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Kidney stones ( 26272126 31729369 19561606) Obsessive-compulsive traits ( 33531474) Red blood cell count ( 32888494) Serum parathyroid hormone levels ( 27927781) Urate levels ( 31578528) Urinary electrolytes (magnesium/calcium ratio) ( 27915449) Urolithiasis ( 30975718)
Interacting Genes		8 interacting genes: CLDN14 CRKL FBXO7 MPDZ PLEKHA2 PTPN13 SH3BP4 SNTG1	4 interacting genes: CTXN3 MAL PLEKHA1 PLLP
Entrez ID		59338	23562
HPRD ID		09686	05727
Ensembl ID		ENSG00000107679	ENSG00000159261
Uniprot IDs		B3KQL5 Q5RGS4 Q9HB21	O95500
PDB IDs		1EAZ
Enriched GO Terms of Interacting Partners?		Tight Junction Assembly Tight Junction Organization Arginyl-tRNA--protein Transferase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Helper T Cell Diapedesis Negative Regulation Of Excitatory Synapse Assembly Protein Arginylation Protein Localization To Vacuole Chordate Pharynx Development Cerebellar Neuron Development Amino Acid Import Lewy Body Core Positive Regulation Of Cell-substrate Adhesion Bicellular Tight Junction Cell-cell Junction Assembly	Structural Constituent Of Myelin Sheath Protein Insertion Into Plasma Membrane Myelination Axon Ensheathment Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Regulation Of Transcytosis Membrane Raft Polarization Positive Regulation Of Protein Folding Peptide-O-fucosyltransferase Activity Protein Localization To Paranode Region Of Axon Compact Myelin Peptidase Activator Activity Involved In Apoptotic Process Protein O-linked Glycosylation Via Fucose Membrane Raft Distribution Granular Component Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Membrane Raft Localization Regulation Of Protein Folding Fucosylation Fucosyltransferase Activity Luteinization Leydig Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?