PLEKHA1

Description		pleckstrin homology domain containing A1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Luteinization Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Ruffle Organization Leydig Cell Differentiation Multicellular Organism Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Protein Localization Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis B Cell Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Roof Of Mouth Development Face Morphogenesis Cellular Response To Hydrogen Peroxide
Pathways		Synthesis of PIPs at the plasma membrane
Drugs		Citric acid
Diseases
GWAS		Age-related macular degeneration ( 23536807 23577725) Age-related macular degeneration (extreme sampling) ( 23577725) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Birth weight ( 27680694 31043758) Central corneal thickness ( 32528159) Femoral neck bone mineral density ( 29499414) Height ( 20189936 31562340) Hip circumference adjusted for BMI ( 34021172) Medication use (thyroid preparations) ( 31015401) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 30718926 30297969 30054458 32499647 28869590 28566273 24509480)
Novel Interacting Genes		1 novel interacting genes: ATE1
Interacting Genes		8 interacting genes: CLDN14 CRKL FBXO7 MPDZ PLEKHA2 PTPN13 SH3BP4 SNTG1
Entrez ID		59338
HPRD ID		09686
Ensembl ID		ENSG00000107679
Uniprot IDs		B3KQL5 Q5RGS4 Q9HB21
PDB IDs		1EAZ
Enriched GO Terms of Interacting Partners?		Tight Junction Assembly Tight Junction Organization Arginyl-tRNA--protein Transferase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Helper T Cell Diapedesis Negative Regulation Of Excitatory Synapse Assembly Protein Arginylation Protein Localization To Vacuole Chordate Pharynx Development Cerebellar Neuron Development Amino Acid Import Lewy Body Core Positive Regulation Of Cell-substrate Adhesion Bicellular Tight Junction Cell-cell Junction Assembly
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