PLEKHA1 and MPDZ

Number of citations of the paper that reports this interaction (PMID 11802782)
18

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PLEKHA1	MPDZ
Gene Name		pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	multiple PDZ domain protein
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Ruffle Membrane Extracellular Vesicular Exosome	Cytoplasm Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cytoplasmic Vesicle Schmidt-Lanterman Incisure Postsynaptic Membrane
	Molecular Function	Protein Binding PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate Binding	Protein Binding Protein C-terminus Binding
	Biological Process	Luteinization Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Phosphatidylinositol 3-kinase Signaling Ruffle Organization Leydig Cell Differentiation Multicellular Organism Growth Establishment Of Protein Localization Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis B Cell Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Palate Development Face Morphogenesis Cellular Response To Hydrogen Peroxide	Cell Adhesion Viral Process Myelination
Pathways
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) Height ( 20189936)	Corneal structure ( 23291589)
Protein-Protein Interactions		5 interactors: CRKL MPDZ PLEKHA2 PTPN13 SH3BP4	13 interactors: ABCA1 CAMK2A CLDN1 CLDN5 CSPG4 DRD3 F11R HTR2C KIT PLEKHA1 PLEKHA2 RNF5 SYNGAP1
Entrez ID		59338	8777
HPRD ID		09686	09155
Ensembl ID		ENSG00000107679	ENSG00000107186
Uniprot IDs		B3KQL5 Q5RGS4 Q9HB21	F5H1U9 O75970
PDB IDs		1EAZ	2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?			Regulation Of Intracellular Signal Transduction Regulation Of Neuronal Synaptic Plasticity Regulation Of Signaling Visual Learning Visual Behavior Associative Learning Regulation Of Synaptic Transmission Regulation Of Signal Transduction Learning Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To Radiation Single-organism Behavior Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Permeability Response To Abiotic Stimulus Negative Regulation Of Protein Kinase B Signaling Behavior Regulation Of MAPK Cascade Cellular Response To Stimulus Signal Transduction Learning Or Memory Cognition Negative Regulation Of Cell Differentiation Regulation Of Lipid Metabolic Process Homeostatic Process Rhythmic Process Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Signaling Response To Light Stimulus Cell Communication Membrane Organization Chemical Homeostasis Positive Regulation Of Metabolic Process Cellular Localization Response To Stress Regulation Of Cell Differentiation Regulation Of CAMP Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Sodium:proton Antiporter Activity Regulation Of Corticotropin-releasing Hormone Secretion Gastric Emptying Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway
Tagcloud ?		abundantly adulthood became belongs contains conversion cytosol dominance dominancy e13 e17 encodes exons gradually homology maintaining overlay p2 phosphoinositides pi3p pi4p pi5p pleckstrin splicing trp ubiquitously ww	a4 ace2 affective affectivity bonferroni combine converting correction endoperoxide exceeded gated nociceptive nonspecific oppera orofacial phenotypes prostaglandin ptgs1 rs10809907 rs1514280 rs3842803 rs466448 rs6432860 scn1a summation temporomandibular thresholds tmd
Tagcloud (Difference) ?		abundantly adulthood became belongs contains conversion cytosol dominance dominancy e13 e17 encodes exons gradually homology maintaining overlay p2 phosphoinositides pi3p pi4p pi5p pleckstrin splicing trp ubiquitously ww	a4 ace2 affective affectivity bonferroni combine converting correction endoperoxide exceeded gated nociceptive nonspecific oppera orofacial phenotypes prostaglandin ptgs1 rs10809907 rs1514280 rs3842803 rs466448 rs6432860 scn1a summation temporomandibular thresholds tmd
Tagcloud (Intersection) ?