PLEKHA1 and PLEKHA2

Number of citations of the paper that reports this interaction (PMID 11802782)
18

Data Source:
BioGRID (two hybrid)

		PLEKHA1	PLEKHA2
Gene Name		pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Ruffle Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Membrane Protein Complex
	Molecular Function	Protein Binding PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate Binding	Fibronectin Binding Protein Binding Lipid Binding Laminin Binding
	Biological Process	Luteinization Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Phosphatidylinositol 3-kinase Signaling Ruffle Organization Leydig Cell Differentiation Multicellular Organism Growth Establishment Of Protein Localization Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis B Cell Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Palate Development Face Morphogenesis Cellular Response To Hydrogen Peroxide	Positive Regulation Of Cell-matrix Adhesion
Pathways
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) Height ( 20189936)
Protein-Protein Interactions		5 interactors: CRKL MPDZ PLEKHA2 PTPN13 SH3BP4	2 interactors: MPDZ PLEKHA1
Entrez ID		59338	59339
HPRD ID		09686
Ensembl ID		ENSG00000107679	ENSG00000169499
Uniprot IDs		B3KQL5 Q5RGS4 Q9HB21	A8K727 Q9HB19
PDB IDs		1EAZ
Enriched GO Terms of Interacting Partners?			Luteinization Leydig Cell Differentiation Phosphatidylinositol 3-kinase Signaling Estrogen Metabolic Process Face Morphogenesis Ruffle Organization Androgen Metabolic Process Negative Regulation Of Protein Kinase B Signaling B Cell Receptor Signaling Pathway Head Morphogenesis Platelet-derived Growth Factor Receptor Signaling Pathway Face Development Body Morphogenesis Cellular Response To Hydrogen Peroxide Ovulation Cycle Process Cellular Response To Reactive Oxygen Species Palate Development Female Gonad Development Multicellular Organism Growth Ovulation Cycle Development Of Primary Female Sexual Characteristics Regulation Of Protein Kinase B Signaling Response To Hydrogen Peroxide Antigen Receptor-mediated Signaling Pathway Phosphatidylinositol-mediated Signaling Post-embryonic Development Myelination Axon Ensheathment Male Gonad Development
Tagcloud ?		abundantly adulthood became belongs contains conversion cytosol dominance dominancy e13 e17 encodes exons gradually homology maintaining overlay p2 phosphoinositides pi3p pi4p pi5p pleckstrin splicing trp ubiquitously ww
Tagcloud (Difference) ?		abundantly adulthood became belongs contains conversion cytosol dominance dominancy e13 e17 encodes exons gradually homology maintaining overlay p2 phosphoinositides pi3p pi4p pi5p pleckstrin splicing trp ubiquitously ww
Tagcloud (Intersection) ?