STX12 and EEA1

Number of citations of the paper that reports this interaction (PMID 10458612)
129

Data Source:
HPRD (in vitro)

		STX12	EEA1
Gene Name		syntaxin 12	early endosome antigen 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endosome Membrane Endomembrane System Integral Component Of Membrane BLOC-1 Complex SNARE Complex Membrane Raft Phagocytic Vesicle Extracellular Vesicular Exosome	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Cytoplasmic Vesicle Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Vesicle Fusion Cholesterol Efflux Vesicle Docking Protein Stabilization	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Early Endosome To Late Endosome Transport
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs			Inositol 1,3-Bisphosphate
Diseases
GWAS
Protein-Protein Interactions		11 interactors: BLOC1S6 DTX2 EEA1 EPB42 HOMER1 NAPA NSG1 SNAP23 SNAP25 SNAP29 STX4	11 interactors: IGF1R MAPK14 RAB22A RAB5A RAB5B RAB5C STX12 STX6 TOM1 USO1 ZFYVE16
Entrez ID		23673	8411
HPRD ID		06059	05460
Ensembl ID		ENSG00000117758	ENSG00000102189
Uniprot IDs		Q86Y82	Q15075
PDB IDs		2DNX	1HYI 1HYJ 1JOC 3MJH
Enriched GO Terms of Interacting Partners?		Membrane Fusion Vesicle Organization Synaptic Vesicle Transport Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Fusion Synaptic Transmission Synaptic Vesicle Exocytosis Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Membrane Organization Cell-cell Signaling Neurotransmitter Secretion Establishment Of Organelle Localization Regulation Of Neurotransmitter Levels Synaptic Vesicle Priming Neurotransmitter Transport Organelle Localization Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Exocytosis Cellular Protein Complex Assembly Secretion By Cell Golgi Vesicle Transport Signaling Secretion Cellular Macromolecular Complex Assembly Synaptic Vesicle Docking Cell Communication Vesicle Docking Establishment Of Localization In Cell Membrane Docking Chemical Homeostasis Within A Tissue Cellular Localization Protein Complex Assembly Protein Localization Organelle Organization Vesicle Targeting Protein Transport Long-term Synaptic Potentiation Establishment Of Protein Localization Transport Regulation Of Synaptic Transmission Intracellular Transport Vesicle Docking Involved In Exocytosis Synaptic Vesicle To Endosome Fusion Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Eosinophil Degranulation SNARE Complex Disassembly Cellular Component Assembly	Intracellular Protein Transport Endosomal Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Rab Protein Signal Transduction Vesicle-mediated Transport Ras Protein Signal Transduction Cellular Localization Endosome Organization Regulation Of Endocytosis Vesicle Fusion Vesicle Organization Plasma Membrane To Endosome Transport Small GTPase Mediated Signal Transduction Organelle Fusion Cytoplasmic Transport Regulation Of Vesicle-mediated Transport Membrane Fusion Transport Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization P38MAPK Cascade Inactivation Of MAPKK Activity Vesicle Docking Membrane Docking Endomembrane System Organization Regulation Of Vesicle Size Golgi Vesicle Docking Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Brown Fat Cell Differentiation Endocytosis Golgi Ribbon Formation Signal Transduction Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Vesicle Fusion With Golgi Apparatus Positive Regulation Of Hormone Biosynthetic Process 3'-UTR-mediated MRNA Stabilization Stress-induced Premature Senescence Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Targeting To Lysosome
Tagcloud ?			appl1 characterised colocalisation colocalises compartments employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst
Tagcloud (Difference) ?			appl1 characterised colocalisation colocalises compartments employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst
Tagcloud (Intersection) ?