STX12 and BLOC1S6

Number of citations of the paper that reports this interaction (PMID 10610180)
29

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		STX12	BLOC1S6
Gene Name		syntaxin 12	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endosome Membrane Endomembrane System Integral Component Of Membrane BLOC-1 Complex SNARE Complex Membrane Raft Phagocytic Vesicle Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Endosome Cytosol Extrinsic Component Of Membrane Transport Vesicle BLOC-1 Complex SNARE Complex
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	Protein Binding Syntaxin Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding
	Biological Process	Intracellular Protein Transport Vesicle Fusion Cholesterol Efflux Vesicle Docking Protein Stabilization	Post-Golgi Vesicle-mediated Transport Blood Coagulation Anterograde Axon Cargo Transport Synaptic Vesicle Docking Melanocyte Differentiation Neuron Projection Development Melanosome Transport Melanosome Organization Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Endosome To Melanosome Transport Anterograde Synaptic Vesicle Transport Positive Regulation Of Pigment Cell Differentiation Membrane Organization Membrane Fusion
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: BLOC1S6 DTX2 EEA1 EPB42 HOMER1 NAPA NSG1 SNAP23 SNAP25 SNAP29 STX4	38 interactors: ABI2 AGGF1 ANK1 APP BLOC1S1 BLOC1S2 BLOC1S4 CCDC136 CCDC22 CCDC53 CCHCR1 CDK5R1 CORO6 DCTN2 DTNBP1 EPS8 EXOC8 HAUS1 IFT20 KRT13 LURAP1 MED21 NDC80 NDN NUP62 OLFM2 PLEKHA5 PLEKHF2 RABGEF1 SKA1 SLC4A1 SMN2 SNAPIN STX11 STX12 SYCE3 TPM3 WDYHV1
Entrez ID		23673	26258
HPRD ID		06059	16055
Ensembl ID		ENSG00000117758	ENSG00000104164
Uniprot IDs		Q86Y82	B3KY40 Q9UL45
PDB IDs		2DNX
Enriched GO Terms of Interacting Partners?		Membrane Fusion Vesicle Organization Synaptic Vesicle Transport Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Fusion Synaptic Transmission Synaptic Vesicle Exocytosis Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Membrane Organization Cell-cell Signaling Neurotransmitter Secretion Establishment Of Organelle Localization Regulation Of Neurotransmitter Levels Synaptic Vesicle Priming Neurotransmitter Transport Organelle Localization Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Exocytosis Cellular Protein Complex Assembly Secretion By Cell Golgi Vesicle Transport Signaling Secretion Cellular Macromolecular Complex Assembly Synaptic Vesicle Docking Cell Communication Vesicle Docking Establishment Of Localization In Cell Membrane Docking Chemical Homeostasis Within A Tissue Cellular Localization Protein Complex Assembly Protein Localization Organelle Organization Vesicle Targeting Protein Transport Long-term Synaptic Potentiation Establishment Of Protein Localization Transport Regulation Of Synaptic Transmission Intracellular Transport Vesicle Docking Involved In Exocytosis Synaptic Vesicle To Endosome Fusion Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Eosinophil Degranulation SNARE Complex Disassembly Cellular Component Assembly	Anterograde Synaptic Vesicle Transport Establishment Of Localization In Cell Axon Cargo Transport Melanosome Organization Pigment Granule Organization Organelle Organization Cellular Pigmentation Anterograde Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Cellular Localization Organelle Localization Synaptic Vesicle Transport Movement Of Cell Or Subcellular Component Establishment Of Vesicle Localization Intracellular Transport Pigmentation Vesicle Organization Establishment Of Organelle Localization Vesicle Localization Membrane Organization Neuron Development Microtubule-based Process Neuron Projection Development Platelet Dense Granule Organization Microtubule-based Movement Cytoskeleton Organization Neuron Differentiation Cell Projection Organization Vesicle-mediated Transport Protein Localization Protein Transport Establishment Of Protein Localization Cell Development Post-Golgi Vesicle-mediated Transport Generation Of Neurons Cellular Protein Localization Neurogenesis Neuron Recognition Secretory Granule Organization Transport Endomembrane System Organization Golgi Vesicle Transport Vesicle Fusion Nervous System Development Mitotic Nuclear Division Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Exocytosis Organelle Fusion
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